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Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples

Authors
Staedler, Davide
Passemard, Solène
Schwung, Sebastian
Dubled, Marc
Schneiter, Guillaume Stéphane
Rytz, Daniel
Gerber-Lemaire, Sandrine
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Published in Nanoscale. 2014, vol. 6, no. 5, p. 2929-2936
Abstract A biophotonics approach based on the nonlinear optical process of second harmonic generation is presented and demonstrated on malignant human cell lines labelled by harmonic nanoparticles. The method enables independent imaging and therapeutic action, selecting each modality by simply tuning the excitation laser wavelength from infrared to visible. In particular, the generation of deep ultraviolet radiation at 270 nm allows direct interaction with nuclear DNA in the absence of photosensitizing molecules.
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STAEDLER, Davide et al. Deep UV generation and direct DNA photo-interaction by harmonic nanoparticles in labelled samples. In: Nanoscale, 2014, vol. 6, n° 5, p. 2929-2936. https://archive-ouverte.unige.ch/unige:37856

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Deposited on : 2014-06-16

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