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Formulations for Local, Magnetically Mediated Hyperthermia Treatment of Solid Tumors

Petri-Fink, Alke
Published in B. Acklin, E. Lautens. Magnetic Nanoparticles: Properties, Synthesis and Applications: Nova Science Publishers. 2012, p. 1-94
Abstract In this chapter we review both preformulation and formulation efforts relevant to magnetically-induced hyperthermia as a new and attractive modality for the treatment of cancer lesions eligible for a thermotherapy. Also addressed are the efforts to apply this method to de novo indications in specific clinical situations. Following a pharmaceutical approach, we first introduce the general biological rationale for the use of hyperthermia, considering the techniques available to generate hyperthermia. We then detail several different magnetically-induced heating modalities and review the literature on formulations in an attempt to compare their specificities, advantages and shortcomings. First, we consider the formulation of glass ceramics and cement biomaterials for magnetically mediated hyperthermia with respect to the biological specificities in the treatment of solid bone tumors. Secondly, formulations intended for magnetically mediated hyperthermia are considered for soft tissue solid tumors, emphasizing the potential for pharmacological modulation. In the final section, we consider magnetic liposome formulations that can be equally administrated in various types of tumors. We do not detail magnetic fluid hyperthermia that uses suspensions of magnetic nanoparticles stabilized by various coatings. Biological and immunological considerations revealed by liposomes are outlined. This chapter focuses on the importance of the formulation and on the highly complex interactions between formulation and hyperthermia that should be considered with respect to various medical applications.
Keywords HyperthermiaOncologyMagnetically-mediatedAMFBoneGlass-ceramicsCementsMicroparticlesEmbolizationIn-situ depotInjectable implantsLiposomesImmunity
ISBN: 978-1-61942-424-1
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Research group Biopharmacie
(ISO format)
LE RENARD, Pol-Edern et al. Formulations for Local, Magnetically Mediated Hyperthermia Treatment of Solid Tumors. In: B. Acklin, E. Lautens (Ed.). Magnetic Nanoparticles: Properties, Synthesis and Applications. [s.l.] : Nova Science Publishers, 2012. p. 1-94. https://archive-ouverte.unige.ch/unige:37842

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Deposited on : 2014-06-16

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