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A user's guide to the encyclopedia of DNA elements (ENCODE)

CollaborationWith : Antonarakis, Stylianos
Published in PLoS biology. 2011, vol. 9, no. 4, e1001046
Abstract The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.
Keywords Base SequenceChromatin/metabolismConserved SequenceDNA MethylationDNA-Binding Proteins/genetics/metabolismDatabases, Nucleic AcidGene ComponentsGene Expression RegulationGenome, HumanHumansInternetModels, GeneticQuality ControlRNA, Messenger/geneticsRNA-Binding Proteins/genetics/metabolism
PMID: 21526222
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Article (Published version) (2.3 MB) - public document Free access
Research group Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
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ENCODE PROJECT CONSORTIUM. A user's guide to the encyclopedia of DNA elements (ENCODE). In: PLoS biology, 2011, vol. 9, n° 4, p. e1001046. doi: 10.1371/journal.pbio.1001046 https://archive-ouverte.unige.ch/unige:37817

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Deposited on : 2014-06-16

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