Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

Rubbia-Brandt, Laura; Audard, V; Sartoretti, Pascal Daniel; Roth, Arnaud; Brezault, C; Le Charpentier, M; Dousset, B; Morel, Philippe; Soubrane, O; Chaussade, S; Mentha, Gilles; Terris, B

doi:10.1093/annonc/mdh095

Scientific article

Open access

English

Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

ContributorsRubbia-Brandt, Laura; Audard, V; Sartoretti, Pascal Daniel; Roth, Arnaud; Brezault, C; Le Charpentier, M; Dousset, B; Morel, Philippe; Soubrane, O; Chaussade, S; Mentha, Gilles; Terris, B

Published inAnnals of oncology, vol. 15, no. 3, p. 460-466

Publication date2004

Abstract

In advanced metastatic colorectal adenocarcinoma, the addition of a neo-adjuvant systemic treatment to surgery might translate into a survival advantage, although this is yet to be confirmed by ongoing randomized trials. The objective of this study was to assess the effects of preoperative systemic chemotherapy on the morphology of non-tumoral liver.

Keywords

Adenocarcinoma/drug therapy/secondary
Adult
Aged
Aged, 80 and over
Antineoplastic Agents/adverse effects/therapeutic use
Cells, Cultured
Colorectal Neoplasms/drug therapy/pathology
Female
Hepatectomy
Hepatic Veno-Occlusive Disease/chemically induced/pathology/surgery
Humans
Liver/drug effects/surgery/ultrastructure
Liver Cirrhosis/chemically induced/pathology/surgery
Liver Neoplasms/secondary/surgery
Male
Middle Aged
Organoplatinum Compounds/adverse effects/therapeutic use
Prognosis

Affiliation

Research group

Citation (ISO format)

RUBBIA-BRANDT, Laura et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. In: Annals of oncology, 2004, vol. 15, n° 3, p. 460–466. doi: 10.1093/annonc/mdh095

Article (Published version)

Identifiers

PID : unige:37177
DOI : 10.1093/annonc/mdh095
PMID : 14998849

ISSN of the journal0923-7534

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Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

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