Scientific article
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English

Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

Published inAnnals of oncology, vol. 15, no. 3, p. 460-466
Publication date2004
Abstract

In advanced metastatic colorectal adenocarcinoma, the addition of a neo-adjuvant systemic treatment to surgery might translate into a survival advantage, although this is yet to be confirmed by ongoing randomized trials. The objective of this study was to assess the effects of preoperative systemic chemotherapy on the morphology of non-tumoral liver.

Keywords
  • Adenocarcinoma/drug therapy/secondary
  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Agents/adverse effects/therapeutic use
  • Cells, Cultured
  • Colorectal Neoplasms/drug therapy/pathology
  • Female
  • Hepatectomy
  • Hepatic Veno-Occlusive Disease/chemically induced/pathology/surgery
  • Humans
  • Liver/drug effects/surgery/ultrastructure
  • Liver Cirrhosis/chemically induced/pathology/surgery
  • Liver Neoplasms/secondary/surgery
  • Male
  • Middle Aged
  • Organoplatinum Compounds/adverse effects/therapeutic use
  • Prognosis
Citation (ISO format)
RUBBIA-BRANDT, Laura et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. In: Annals of oncology, 2004, vol. 15, n° 3, p. 460–466. doi: 10.1093/annonc/mdh095
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
Journal ISSN0923-7534
798views
863downloads

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