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Title

Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

Authors
Audard, V
Brezault, C
Le Charpentier, M
Dousset, B
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Published in Annals of Oncology. 2004, vol. 15, no. 3, p. 460-6
Abstract In advanced metastatic colorectal adenocarcinoma, the addition of a neo-adjuvant systemic treatment to surgery might translate into a survival advantage, although this is yet to be confirmed by ongoing randomized trials. The objective of this study was to assess the effects of preoperative systemic chemotherapy on the morphology of non-tumoral liver.
Keywords Adenocarcinoma/drug therapy/secondaryAdultAgedAged, 80 and overAntineoplastic Agents/adverse effects/therapeutic useCells, CulturedColorectal Neoplasms/drug therapy/pathologyFemaleHepatectomyHepatic Veno-Occlusive Disease/chemically induced/pathology/surgeryHumansLiver/drug effects/surgery/ultrastructureLiver Cirrhosis/chemically induced/pathology/surgeryLiver Neoplasms/secondary/surgeryMaleMiddle AgedOrganoplatinum Compounds/adverse effects/therapeutic usePrognosis
Identifiers
PMID: 14998849
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Article (Published version) (3.7 MB) - public document Free access
Structures
Research groups Métastases du foie (657)
Groupe Roth Arnaud (oncologie) (285)
Chirurgie viscérale (104)
Hépatologie chirurgicale (327)
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RUBBIA-BRANDT, Laura et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. In: Annals of Oncology, 2004, vol. 15, n° 3, p. 460-6. https://archive-ouverte.unige.ch/unige:37177

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Deposited on : 2014-06-04

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