Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer

Rubbia-Brandt, Laura; Audard, V; Sartoretti, Pascal Daniel; Roth, Arnaud; Brezault, C; Le Charpentier, M; Dousset, B; Morel, Philippe; Soubrane, O; Chaussade, S; Mentha, Gilles; Terris, B

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Title		Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer
Authors		Rubbia-Brandt, Laura Audard, V Sartoretti, Pascal Daniel Roth, Arnaud Brezault, C Le Charpentier, M Dousset, B Morel, Philippe Soubrane, O Chaussade, S Mentha, Gilles Terris, B show all authors [1 - 12]
Published in		Annals of Oncology. 2004, vol. 15, no. 3, p. 460-6
Abstract		In advanced metastatic colorectal adenocarcinoma, the addition of a neo-adjuvant systemic treatment to surgery might translate into a survival advantage, although this is yet to be confirmed by ongoing randomized trials. The objective of this study was to assess the effects of preoperative systemic chemotherapy on the morphology of non-tumoral liver.
Keywords		Adenocarcinoma/drug therapy/secondary — Adult — Aged — Aged, 80 and over — Antineoplastic Agents/adverse effects/therapeutic use — Cells, Cultured — Colorectal Neoplasms/drug therapy/pathology — Female — Hepatectomy — Hepatic Veno-Occlusive Disease/chemically induced/pathology/surgery — Humans — Liver/drug effects/surgery/ultrastructure — Liver Cirrhosis/chemically induced/pathology/surgery — Liver Neoplasms/secondary/surgery — Male — Middle Aged — Organoplatinum Compounds/adverse effects/therapeutic use — Prognosis
Identifiers		DOI: 10.1093/annonc/mdh095 PMID: 14998849
Full text		Article (Published version) (3.7 MB) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research groups		Métastases du foie (657) Groupe Roth Arnaud (oncologie) (285) Chirurgie viscérale (104) Hépatologie chirurgicale (327)
Citation (ISO format)		RUBBIA-BRANDT, Laura et al. Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer. In: Annals of Oncology, 2004, vol. 15, n° 3, p. 460-6. https://archive-ouverte.unige.ch/unige:37177