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Title

Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study

Authors
Trinquand, Amélie
Tanguy-Schmidt, Aline
Ben Abdelali, Raouf
Lambert, Jérôme
Beldjord, Kheira
Lengliné, Etienne
De Gunzburg, Noémie
Payet-Bornet, Dominique
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Published in Journal of Clinical Oncology. 2013, vol. 31, no. 34, p. 4333-42
Abstract The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and/or FBXW7 (N/F) mutations compared with unmutated T-ALL. Despite this, one third of patients with N/F-mutated T-ALL experienced relapse.
Keywords AdultCell Cycle Proteins/geneticsDNA Mutational AnalysisDisease-Free SurvivalF-Box Proteins/geneticsFemaleGTP Phosphohydrolases/geneticsGene DeletionGenetic Predisposition to DiseaseHumansKaplan-Meier EstimateMaleMembrane Proteins/geneticsMultivariate AnalysisMutationPTEN Phosphohydrolase/geneticsPhenotypePrecursor T-Cell Lymphoblastic Leukemia-Lymphoma/classification/genetics/mortality/therapyPredictive Value of TestsProportional Hazards ModelsProto-Oncogene Proteins/geneticsReceptor, Notch1/geneticsRisk FactorsTime FactorsUbiquitin-Protein Ligases/geneticsYoung AdultRas Proteins/genetics
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PMID: 24166518
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TRINQUAND, Amélie et al. Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study. In: Journal of Clinical Oncology, 2013, vol. 31, n° 34, p. 4333-42. https://archive-ouverte.unige.ch/unige:37149

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Deposited on : 2014-06-04

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