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Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study

Published inJournal of clinical oncology, vol. 31, no. 34, p. 4333-4342
Publication date2013
Abstract

The Group for Research in Adult Acute Lymphoblastic Leukemia (GRAALL) recently reported a significantly better outcome in T-cell acute lymphoblastic leukemia (T-ALL) harboring NOTCH1 and/or FBXW7 (N/F) mutations compared with unmutated T-ALL. Despite this, one third of patients with N/F-mutated T-ALL experienced relapse.

Keywords
  • Adult
  • Cell Cycle Proteins/genetics
  • DNA Mutational Analysis
  • Disease-Free Survival
  • F-Box Proteins/genetics
  • Female
  • GTP Phosphohydrolases/genetics
  • Gene Deletion
  • Genetic Predisposition to Disease
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Membrane Proteins/genetics
  • Multivariate Analysis
  • Mutation
  • PTEN Phosphohydrolase/genetics
  • Phenotype
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/classification/genetics/mortality/therapy
  • Predictive Value of Tests
  • Proportional Hazards Models
  • Proto-Oncogene Proteins/genetics
  • Receptor, Notch1/genetics
  • Risk Factors
  • Time Factors
  • Ubiquitin-Protein Ligases/genetics
  • Young Adult
  • Ras Proteins/genetics
Citation (ISO format)
TRINQUAND, Amélie et al. Toward a NOTCH1/FBXW7/RAS/PTEN-based oncogenetic risk classification of adult T-cell acute lymphoblastic leukemia: a Group for Research in Adult Acute Lymphoblastic Leukemia study. In: Journal of clinical oncology, 2013, vol. 31, n° 34, p. 4333–4342. doi: 10.1200/JCO.2012.48.5292
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0732-183X
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