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Harmonic Nanocrystals for Biolabeling: A Survey of Optical Properties and Biocompatibility

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Hadji, Rachid
Joulaud, Cécile
Schwung, Sebastian
Passemard, Solène
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Published in ACS Nano. 2012, vol. 6, no. 3, p. 2542-2549
Abstract Nonlinear optical nanocrystals have been recently introduced as a promising alternative to fluorescent probes for multiphoton microscopy. We present for the first time a complete survey of the properties of five nanomaterials (KNbO3, LiNbO3, BaTiO3, KTP, and ZnO), describing their preparation and stabilization and providing quantitative estimations of their nonlinear optical response. In the light of their prospective use as biological and clinical markers, we assess their biocompatibility on human healthy and cancerous cell lines. Finally, we demonstrate the great potential for cell imaging of these inherently nonlinear probes in terms of optical contrast, wavelength flexibility, and signal photostability.
Keywords Harmonic nanoparticlesNonlinear microscopyCell labeling
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Other version: http://pubs.acs.org/doi/abs/10.1021/nn204990n
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STAEDLER, Davide et al. Harmonic Nanocrystals for Biolabeling: A Survey of Optical Properties and Biocompatibility. In: ACS Nano, 2012, vol. 6, n° 3, p. 2542-2549. https://archive-ouverte.unige.ch/unige:37107

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Deposited on : 2014-06-03

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