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Title

Drug-eluting beads loaded with antiangiogenic agents for chemoembolization: in vitro sunitinib loading and release and in vivo pharmacokinetics in an animal model

Authors
Bize, Pierre E
Dormond, Olivier
Denys, Alban
Published in Journal of Vascular and Interventional Radiology. 2014, vol. 25, no. 3, p. 379-87,387.e1-2
Abstract The combination of embolic beads with a multitargeted tyrosine kinase inhibitor that inhibits tumor vessel growth is suggested as an alternative and improvement to the current standard doxorubicin-eluting beads for use in transarterial chemoembolization. This study demonstrates the in vitro loading and release kinetics of sunitinib using commercially available embolization microspheres and evaluates the in vitro biologic efficacy on cell cultures and the resulting in vivo pharmacokinetics profiles in an animal model.
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PMID: 24468044
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FUCHS, Katrin et al. Drug-eluting beads loaded with antiangiogenic agents for chemoembolization: in vitro sunitinib loading and release and in vivo pharmacokinetics in an animal model. In: Journal of Vascular and Interventional Radiology, 2014, vol. 25, n° 3, p. 379-87,387.e1-2. https://archive-ouverte.unige.ch/unige:37016

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Deposited on : 2014-05-30

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