Drug-eluting beads loaded with antiangiogenic agents for chemoembolization: in vitro sunitinib loading and release and in vivo pharmacokinetics in an animal model

Fuchs, Katrin; Bize, Pierre E; Dormond, Olivier; Denys, Alban; Doelker, Eric; Borchard, Gerrit; Jordan, Olivier

doi:10.1016/j.jvir.2013.11.039

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Title		Drug-eluting beads loaded with antiangiogenic agents for chemoembolization: in vitro sunitinib loading and release and in vivo pharmacokinetics in an animal model
Authors		Fuchs, Katrin Bize, Pierre E Dormond, Olivier Denys, Alban Doelker, Eric Borchard, Gerrit Jordan, Olivier
Published in		Journal of vascular and interventional radiology. 2014, vol. 25, no. 3, p. 379-87,387.e1-2
Abstract		The combination of embolic beads with a multitargeted tyrosine kinase inhibitor that inhibits tumor vessel growth is suggested as an alternative and improvement to the current standard doxorubicin-eluting beads for use in transarterial chemoembolization. This study demonstrates the in vitro loading and release kinetics of sunitinib using commercially available embolization microspheres and evaluates the in vitro biologic efficacy on cell cultures and the resulting in vivo pharmacokinetics profiles in an animal model.
Identifiers		DOI: 10.1016/j.jvir.2013.11.039 PMID: 24468044
Full text		Article (Published version) (399 Kb) - Limited access to UNIGE Article (Accepted version) (1.3 MB) - Free access
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Citation (ISO format)		FUCHS, Katrin et al. Drug-eluting beads loaded with antiangiogenic agents for chemoembolization: in vitro sunitinib loading and release and in vivo pharmacokinetics in an animal model. In: Journal of vascular and interventional radiology, 2014, vol. 25, n° 3, p. 379-87,387.e1-2. doi: 10.1016/j.jvir.2013.11.039 https://archive-ouverte.unige.ch/unige:37016