Progressive tissue injury in burns is reduced by rNAPc2

Mahajan, Ajay Liladhar; Tenorio, Xavier; Pepper, Michael Sean; Baetens Baumann, Danielle; Montandon, Denys; Schlaudraff, Kai-Uwe; Pittet Cuenod, Brigitte Maud

doi:10.1016/j.burns.2006.02.010

Scientific article

English

Progressive tissue injury in burns is reduced by rNAPc2

ContributorsMahajan, Ajay Liladhar; Tenorio, Xavier; Pepper, Michael Sean; Baetens Baumann, Danielle; Montandon, Denys; Schlaudraff, Kai-Uwe; Pittet Cuenod, Brigitte Maud

Published inBurns, vol. 32, no. 8, p. 957-963

Publication date2006

Abstract

Burn wounds are characterised by central necrosis surrounded by an area of stasis with compromised perfusion. Secondary aggravation of the burn wound due to ischaemia in the zone of stasis can also result in necrosis. This study aims to improve circulation in the zone of stasis by reducing microthrombus formation and thereby to reduce secondary aggravation.

Keywords

Animals
Anticoagulants/therapeutic use
Burns/drug therapy/pathology
Cicatrix
Contracture/prevention & control
Fibrin/analysis
Flow Cytometry
Helminth Proteins/therapeutic use
Male
Random Allocation
Rats
Rats, Wistar
Recombinant Proteins/therapeutic use
Regional Blood Flow/drug effects

Affiliation entities

Research groups

Groupe Pittet Cuenod Brigitte (chirurgie plastique et reconstructive) (96)

Citation (ISO format)

MAHAJAN, Ajay Liladhar et al. Progressive tissue injury in burns is reduced by rNAPc2. In: Burns, 2006, vol. 32, n° 8, p. 957–963. doi: 10.1016/j.burns.2006.02.010

Article (Published version)

Identifiers

PID : unige:37009
DOI : 10.1016/j.burns.2006.02.010
PMID : 16905262

Journal ISSN0305-4179

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Progressive tissue injury in burns is reduced by rNAPc2

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