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Hepatopulmonary syndrome increases the postoperative mortality rate following liver transplantation: a prospective study in 90 patients

Contributors

Schiffer, Eduardo; Majno, Pietro; Mentha, Gilles; Giostra, Emiliano; Burri, Haran Kumar; Klopfenstein, Claude-Eric; Beaussier, M; Morel, Philippe; Hadengue, Antoine; Pastor, Catherine

Published in

American journal of transplantation, vol. 6, no. 6, p. 1430-1437

Publication date

2006

Abstract

Hepatopulmonary syndrome (HPS) is a frequent pulmonary complication of patients with end-stage liver diseases. HPS is diagnosed by hypoxemia and pulmonary vascular dilatation and is an independent risk factor of mortality. Orthotopic liver transplantation (OLT) is the only factor that modifies the natural course of HPS. Once patients with HPS have been transplanted, their long-term survival rate is similar to transplanted patients without HPS. Consequently, HPS is an indication of OLT whatever the severity of hypoxemia. However, besides the favorable long-term survival of HPS patients with OLT, a high postoperative mortality (mostly within 6 months) has been suggested. The aim of our study was to analyze the incidence of HPS and postoperative outcome after OLT in 90 consecutive patients. All patients were prospectively included and had blood gas analysis to detect HPS. Patients with hypoxemia had contrast echocardiography to confirm HPS. Nine patients had HPS with a 50 50 mmHg in all HPS patients transplanted.

Keywords

  • Adult
  • Aged
  • Blood Gas Analysis
  • Female
  • Follow-Up Studies
  • Hepatopulmonary Syndrome/blood/mortality/surgery/ultrasonography
  • Humans
  • Liver Transplantation/mortality
  • Male
  • Middle Aged
  • Patient Selection
  • Prospective Studies
  • Survival Rate
  • Time Factors

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

SCHIFFER, Eduardo et al. Hepatopulmonary syndrome increases the postoperative mortality rate following liver transplantation: a prospective study in 90 patients. In: American journal of transplantation, 2006, vol. 6, n° 6, p. 1430–1437. doi: 10.1111/j.1600-6143.2006.01334.x

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1600-6135
930views
678downloads

Technical informations

Creation

27/05/2014 16:41:00

First validation

27/05/2014 16:41:00

Update

14/03/2023 21:16:19

Status update

14/03/2023 21:16:18

Last indexation

06/10/2025 09:20:23
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