Low resolution in the indirect dimension of 1H–13C heteronuclear experiments is a long-standing problem of NMR spectroscopy, which has not found a satisfactory solution. Among the numerous techniques aiming at increasing the resolution of the indirect dimension of 2D NMR spectra, we focused on spectral aliasing, which plays a unique role for its simplicity of application and efficiency. We also developed a homonuclear 13C decoupling in the F1 dimension, which enhances sensitivity and resolution by transforming the spread of multiplet patterns of carbons into singlets when samples with 13C labeling are involved.