Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination

Legout, Laurence; Senneville, E; Stern, Richard; Yazdanpanah, Y; Savage, C; Roussel-Delvalez, M; Rosele, B; Migaud, H; Mouton, Y

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Title		Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination
Authors		Legout, Laurence Senneville, E Stern, Richard Yazdanpanah, Y Savage, C Roussel-Delvalez, M Rosele, B Migaud, H Mouton, Y show all authors [1 - 9]
Published in		Clinical Microbiology and Infection. 2006, vol. 12, no. 10, p. 1030-3
Abstract		A 3-year retrospective study evaluated the effectiveness and safety of cefepime plus a fluoroquinolone for treating bone and joint infections caused by Gram-negative bacilli (GNB) in 28 patients. Intra-operative cultures yielded primarily Pseudomonas spp. and Enterobacter cloacae. Full recovery (cure) was observed in 79% of patients. There were no serious adverse effects and no resistant organisms were isolated. The results of the study confirmed the safety and effectiveness of cefepime combined with a fluoroquinolone for the treatment of bone and joint infections caused by Gram-negative bacilli.
Keywords		Adult — Aged — Aged, 80 and over — Anti-Bacterial Agents/administration & dosage/therapeutic use — Bone Diseases, Infectious/drug therapy — Cephalosporins/administration & dosage/therapeutic use — Ciprofloxacin/administration & dosage/therapeutic use — Drug Therapy, Combination — Female — Gram-Negative Bacterial Infections/drug therapy — Humans — Joint Diseases/drug therapy — Male — Middle Aged — Ofloxacin/administration & dosage/therapeutic use — Retrospective Studies
Identifiers		DOI: 10.1111/j.1469-0691.2006.01523.x PMID: 16961643
Full text		Article (Published version) (443 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research group		Chirurgie orthopédique et traumatologique (98)
Citation (ISO format)		LEGOUT, Laurence et al. Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination. In: Clinical Microbiology and Infection, 2006, vol. 12, n° 10, p. 1030-3. https://archive-ouverte.unige.ch/unige:36977