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Title

Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination

Authors
Senneville, E
Yazdanpanah, Y
Savage, C
Roussel-Delvalez, M
Rosele, B
Migaud, H
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Published in Clinical Microbiology and Infection. 2006, vol. 12, no. 10, p. 1030-3
Abstract A 3-year retrospective study evaluated the effectiveness and safety of cefepime plus a fluoroquinolone for treating bone and joint infections caused by Gram-negative bacilli (GNB) in 28 patients. Intra-operative cultures yielded primarily Pseudomonas spp. and Enterobacter cloacae. Full recovery (cure) was observed in 79% of patients. There were no serious adverse effects and no resistant organisms were isolated. The results of the study confirmed the safety and effectiveness of cefepime combined with a fluoroquinolone for the treatment of bone and joint infections caused by Gram-negative bacilli.
Keywords AdultAgedAged, 80 and overAnti-Bacterial Agents/administration & dosage/therapeutic useBone Diseases, Infectious/drug therapyCephalosporins/administration & dosage/therapeutic useCiprofloxacin/administration & dosage/therapeutic useDrug Therapy, CombinationFemaleGram-Negative Bacterial Infections/drug therapyHumansJoint Diseases/drug therapyMaleMiddle AgedOfloxacin/administration & dosage/therapeutic useRetrospective Studies
Identifiers
PMID: 16961643
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Structures
Research group Chirurgie orthopédique et traumatologique (98)
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(ISO format)
LEGOUT, Laurence et al. Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination. In: Clinical Microbiology and Infection, 2006, vol. 12, n° 10, p. 1030-3. https://archive-ouverte.unige.ch/unige:36977

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Deposited on : 2014-05-27

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