Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination

Legout, Laurence; Senneville, E; Stern, Richard; Yazdanpanah, Y; Savage, C; Roussel-Delvalez, M; Rosele, B; Migaud, H; Mouton, Y

doi:10.1111/j.1469-0691.2006.01523.x

Scientific article

English

Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination

ContributorsLegout, Laurence; Senneville, E; Stern, Richard; Yazdanpanah, Y; Savage, C; Roussel-Delvalez, M; Rosele, B; Migaud, H; Mouton, Y

Published inClinical microbiology and infection, vol. 12, no. 10, p. 1030-1033

Publication date2006

Abstract

A 3-year retrospective study evaluated the effectiveness and safety of cefepime plus a fluoroquinolone for treating bone and joint infections caused by Gram-negative bacilli (GNB) in 28 patients. Intra-operative cultures yielded primarily Pseudomonas spp. and Enterobacter cloacae. Full recovery (cure) was observed in 79% of patients. There were no serious adverse effects and no resistant organisms were isolated. The results of the study confirmed the safety and effectiveness of cefepime combined with a fluoroquinolone for the treatment of bone and joint infections caused by Gram-negative bacilli.

Keywords

Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents/administration & dosage/therapeutic use
Bone Diseases, Infectious/drug therapy
Cephalosporins/administration & dosage/therapeutic use
Ciprofloxacin/administration & dosage/therapeutic use
Drug Therapy, Combination
Female
Gram-Negative Bacterial Infections/drug therapy
Humans
Joint Diseases/drug therapy
Male
Middle Aged
Ofloxacin/administration & dosage/therapeutic use
Retrospective Studies

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Chirurgie orthopédique et traumatologique (98)

Citation (ISO format)

LEGOUT, Laurence et al. Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination. In: Clinical microbiology and infection, 2006, vol. 12, n° 10, p. 1030–1033. doi: 10.1111/j.1469-0691.2006.01523.x

Article (Published version)

Identifiers

PID : unige:36977
DOI : 10.1111/j.1469-0691.2006.01523.x
PMID : 16961643

Journal ISSN1198-743X

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Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination

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