en
Scientific article
English

Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination

Published inClinical microbiology and infection, vol. 12, no. 10, p. 1030-1033
Publication date2006
Abstract

A 3-year retrospective study evaluated the effectiveness and safety of cefepime plus a fluoroquinolone for treating bone and joint infections caused by Gram-negative bacilli (GNB) in 28 patients. Intra-operative cultures yielded primarily Pseudomonas spp. and Enterobacter cloacae. Full recovery (cure) was observed in 79% of patients. There were no serious adverse effects and no resistant organisms were isolated. The results of the study confirmed the safety and effectiveness of cefepime combined with a fluoroquinolone for the treatment of bone and joint infections caused by Gram-negative bacilli.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents/administration & dosage/therapeutic use
  • Bone Diseases, Infectious/drug therapy
  • Cephalosporins/administration & dosage/therapeutic use
  • Ciprofloxacin/administration & dosage/therapeutic use
  • Drug Therapy, Combination
  • Female
  • Gram-Negative Bacterial Infections/drug therapy
  • Humans
  • Joint Diseases/drug therapy
  • Male
  • Middle Aged
  • Ofloxacin/administration & dosage/therapeutic use
  • Retrospective Studies
Citation (ISO format)
LEGOUT, Laurence et al. Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination. In: Clinical microbiology and infection, 2006, vol. 12, n° 10, p. 1030–1033. doi: 10.1111/j.1469-0691.2006.01523.x
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Article (Published version)
accessLevelRestricted
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ISSN of the journal1198-743X
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