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Scientific article
English

Endothelial Cx40 limits myocardial ischaemia/reperfusion injury in mice

Published inCardiovascular research, vol. 102, no. 2, p. 329-337
Publication date2014
Abstract

Gap junctions are indispensable for the function of heart and blood vessels by providing electrical coupling and direct cell-to-cell transfer of small signalling molecules. Gap junction channels between neighbouring cells are composed of 12 connexins (Cx). Changes in Cx43 expression, localization, and channel properties in cardiomyocytes contribute to infarction and reperfusion injury of the heart. It is increasingly recognized that deleterious consequences of ischaemia/reperfusion (IR) are modulated by the inflammatory response and endothelial function. The role of the endothelial connexins, i.e. Cx40 and Cx37, in cardiac IR injury is, however, not known.

Citation (ISO format)
MOREL, Sandrine et al. Endothelial Cx40 limits myocardial ischaemia/reperfusion injury in mice. In: Cardiovascular research, 2014, vol. 102, n° 2, p. 329–337. doi: 10.1093/cvr/cvu063
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ISSN of the journal0008-6363
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