Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme

Koch, M; Wehrle-Haller, Bernhard; Baumgartner, S; Spring, J; Brubacher, D; Chiquet, M

doi:10.1016/0014-4827(91)90368-5

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Title		Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme
Authors		Koch, M Wehrle-Haller, Bernhard Baumgartner, S Spring, J Brubacher, D Chiquet, M
Published in		Experimental cell research. 1991, vol. 194, no. 2, p. 297-300
Abstract		The extracellular matrix protein, tenascin, has been proposed as mediator in epithelial-mesenchymal interactions because of its characteristic distribution during embryogenesis. Here we compared the accumulation of tenascin and laminin in the early chicken lung bud. Laminin is deposited in the basement membrane, starting at the tips and increasing along the shafts of growing primary and secondary bronchi. In contrast, tenascin accumulation is highest in basement membranes and mesenchyme at sites where new bronchial branches are formed. By in situ hybridization, tenascin mRNA was found to be produced exclusively by the epithelium at sites of active growth of bronchial tubes.
Keywords		Animals — Antibodies, Monoclonal/diagnostic use — Basement Membrane/cytology/physiology — Bronchi/cytology/physiology — Cell Adhesion Molecules, Neuronal/analysis/biosynthesis/genetics — Chick Embryo — Cloning, Molecular — Epithelial Cells — Epithelium/physiology — Extracellular Matrix Proteins/analysis/biosynthesis/genetics — Fluorescent Antibody Technique — Laminin/analysis — Nucleic Acid Hybridization — Tenascin
Identifiers		DOI: 10.1016/0014-4827(91)90368-5 PMID: 1709104
Full text		Article (Published version) (3.9 MB) - Free access
Structures		Faculté de médecine
Research group		Migration cellulaire (645)
Citation (ISO format)		KOCH, M et al. Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme. In: Experimental cell research, 1991, vol. 194, n° 2, p. 297-300. doi: 10.1016/0014-4827(91)90368-5 https://archive-ouverte.unige.ch/unige:36650