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English

Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme

Contributors

Koch, M; Wehrle-Haller, Bernhard; Baumgartner, S; Spring, J; Brubacher, D; Chiquet, M

Published in

Experimental cell research, vol. 194, no. 2, p. 297-300

Publication date

1991

Abstract

The extracellular matrix protein, tenascin, has been proposed as mediator in epithelial-mesenchymal interactions because of its characteristic distribution during embryogenesis. Here we compared the accumulation of tenascin and laminin in the early chicken lung bud. Laminin is deposited in the basement membrane, starting at the tips and increasing along the shafts of growing primary and secondary bronchi. In contrast, tenascin accumulation is highest in basement membranes and mesenchyme at sites where new bronchial branches are formed. By in situ hybridization, tenascin mRNA was found to be produced exclusively by the epithelium at sites of active growth of bronchial tubes.

Keywords

  • Animals
  • Antibodies, Monoclonal/diagnostic use
  • Basement Membrane/cytology/physiology
  • Bronchi/cytology/physiology
  • Cell Adhesion Molecules, Neuronal/analysis/biosynthesis/genetics
  • Chick Embryo
  • Cloning, Molecular
  • Epithelial Cells
  • Epithelium/physiology
  • Extracellular Matrix Proteins/analysis/biosynthesis/genetics
  • Fluorescent Antibody Technique
  • Laminin/analysis
  • Nucleic Acid Hybridization
  • Tenascin

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

KOCH, M et al. Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme. In: Experimental cell research, 1991, vol. 194, n° 2, p. 297–300. doi: 10.1016/0014-4827(91)90368-5

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

0014-4827
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507downloads

Technical informations

Creation

14/05/2014 14:00:00

First validation

14/05/2014 14:00:00

Update

14/03/2023 21:14:07

Status update

14/03/2023 21:14:07

Last indexation

12/11/2024 17:00:07
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