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Title

Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme
Authors
Koch, M
Wehrle-Haller, Bernhard
Baumgartner, S
Spring, J
Brubacher, D
Chiquet, M
Published in Experimental Cell Research. 1991, vol. 194, no. 2, p. 297-300
Abstract The extracellular matrix protein, tenascin, has been proposed as mediator in epithelial-mesenchymal interactions because of its characteristic distribution during embryogenesis. Here we compared the accumulation of tenascin and laminin in the early chicken lung bud. Laminin is deposited in the basement membrane, starting at the tips and increasing along the shafts of growing primary and secondary bronchi. In contrast, tenascin accumulation is highest in basement membranes and mesenchyme at sites where new bronchial branches are formed. By in situ hybridization, tenascin mRNA was found to be produced exclusively by the epithelium at sites of active growth of bronchial tubes.
Keywords Animals — Antibodies, Monoclonal/diagnostic use — Basement Membrane/cytology/physiology — Bronchi/cytology/physiology — Cell Adhesion Molecules, Neuronal/analysis/biosynthesis/genetics — Chick Embryo — Cloning, Molecular — Epithelial Cells — Epithelium/physiology — Extracellular Matrix Proteins/analysis/biosynthesis/genetics — Fluorescent Antibody Technique — Laminin/analysis — Nucleic Acid Hybridization — Tenascin
Identifiers
PMID: 1709104
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Article (Published version) (3.9 MB) - public document Free access
Structures
Faculté de médecine
Research group Migration cellulaire (645)
Citation
(ISO format) 		KOCH, M et al. Epithelial synthesis of tenascin at tips of growing bronchi and graded accumulation in basement membrane and mesenchyme. In: Experimental Cell Research, 1991, vol. 194, n° 2, p. 297-300. https://archive-ouverte.unige.ch/unige:36650

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