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Anti-CD79 antibody induces B cell anergy that protects against autoimmunity

Hardy, Ian R
Anceriz, Nadia
Rousseau, François
Seefeldt, Matt B
Hatterer, Eric
Buatois, Vanessa
Chatel, Laurence E
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Published in The Journal of immunology. 2014, vol. 192, no. 4, p. 1641-50
Abstract B cells play a major role in the pathogenesis of many autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and type I diabetes mellitus, as indicated by the efficacy of B cell-targeted therapies in these diseases. Therapeutic effects of the most commonly used B cell-targeted therapy, anti-CD20 mAb, are contingent upon long-term depletion of peripheral B cells. In this article, we describe an alternative approach involving the targeting of CD79, the transducer subunit of the B cell AgR. Unlike anti-CD20 mAbs, the protective effects of CD79-targeted mAbs do not require cell depletion; rather, they act by inducing an anergic-like state. Thus, we describe a novel B cell-targeted approach predicated on the induction of B cell anergy.
Keywords AnimalsAntibodies, Monoclonal/immunologyAntigens, CD79/immunologyAutoimmune Diseases/prevention & controlAutoimmunity/immunologyB-Lymphocytes/immunologyClonal Anergy/immunologyFemaleLymphocyte Activation/immunologyLymphocyte CountLymphocyte DepletionMaleMiceMice, Inbred C57BLMice, Inbred DBAMice, Knockout
PMID: 24442438
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Research group Groupe Reith Walter (pathologie et immunologie) (282)
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HARDY, Ian R et al. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. In: The Journal of immunology, 2014, vol. 192, n° 4, p. 1641-50. doi: 10.4049/jimmunol.1302672 https://archive-ouverte.unige.ch/unige:36446

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Deposited on : 2014-05-09

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