UNIGE document Scientific Article
previous document  unige:36446  next document
add to browser collection
Title

Anti-CD79 antibody induces B cell anergy that protects against autoimmunity

Authors
Hardy, Ian R
Anceriz, Nadia
Rousseau, François
Seefeldt, Matt B
Hatterer, Eric
Buatois, Vanessa
Chatel, Laurence E
show hidden authors show all authors [1 - 20]
Published in Journal of Immunology. 2014, vol. 192, no. 4, p. 1641-50
Abstract B cells play a major role in the pathogenesis of many autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and type I diabetes mellitus, as indicated by the efficacy of B cell-targeted therapies in these diseases. Therapeutic effects of the most commonly used B cell-targeted therapy, anti-CD20 mAb, are contingent upon long-term depletion of peripheral B cells. In this article, we describe an alternative approach involving the targeting of CD79, the transducer subunit of the B cell AgR. Unlike anti-CD20 mAbs, the protective effects of CD79-targeted mAbs do not require cell depletion; rather, they act by inducing an anergic-like state. Thus, we describe a novel B cell-targeted approach predicated on the induction of B cell anergy.
Keywords AnimalsAntibodies, Monoclonal/immunologyAntigens, CD79/immunologyAutoimmune Diseases/prevention & controlAutoimmunity/immunologyB-Lymphocytes/immunologyClonal Anergy/immunologyFemaleLymphocyte Activation/immunologyLymphocyte CountLymphocyte DepletionMaleMiceMice, Inbred C57BLMice, Inbred DBAMice, Knockout
Identifiers
PMID: 24442438
Full text
Article (Published version) (1.8 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Groupe Reith Walter (pathologie et immunologie) (282)
Citation
(ISO format)
HARDY, Ian R et al. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. In: Journal of Immunology, 2014, vol. 192, n° 4, p. 1641-50. doi: 10.4049/jimmunol.1302672 https://archive-ouverte.unige.ch/unige:36446

467 hits

0 download

Update

Deposited on : 2014-05-09

Export document
Format :
Citation style :