Anti-CD79 antibody induces B cell anergy that protects against autoimmunity

Hardy, Ian R; Anceriz, Nadia; Rousseau, François; Seefeldt, Matt B; Hatterer, Eric; Irla, Magali; Buatois, Vanessa; Chatel, Laurence E; Getahun, Andrew; Fletcher, Ashley; Cons, Laura; Pontini, Guillemette; Hertzberg, Nicole A; Magistrelli, Giovanni; Malinge, Pauline; Smith, Mia J; Reith, Walter; Kosco-Vilbois, Marie H; Ferlin, Walter G; Cambier, John C

doi:10.4049/jimmunol.1302672

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Title		Anti-CD79 antibody induces B cell anergy that protects against autoimmunity
Authors		Hardy, Ian R Anceriz, Nadia Rousseau, François Seefeldt, Matt B Hatterer, Eric Irla, Magali Buatois, Vanessa Chatel, Laurence E Getahun, Andrew Fletcher, Ashley Cons, Laura Pontini, Guillemette Hertzberg, Nicole A Magistrelli, Giovanni Malinge, Pauline Smith, Mia J Reith, Walter Kosco-Vilbois, Marie H Ferlin, Walter G Cambier, John C show all authors [1 - 20]
Published in		Journal of Immunology. 2014, vol. 192, no. 4, p. 1641-50
Abstract		B cells play a major role in the pathogenesis of many autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and type I diabetes mellitus, as indicated by the efficacy of B cell-targeted therapies in these diseases. Therapeutic effects of the most commonly used B cell-targeted therapy, anti-CD20 mAb, are contingent upon long-term depletion of peripheral B cells. In this article, we describe an alternative approach involving the targeting of CD79, the transducer subunit of the B cell AgR. Unlike anti-CD20 mAbs, the protective effects of CD79-targeted mAbs do not require cell depletion; rather, they act by inducing an anergic-like state. Thus, we describe a novel B cell-targeted approach predicated on the induction of B cell anergy.
Keywords		Animals — Antibodies, Monoclonal/immunology — Antigens, CD79/immunology — Autoimmune Diseases/prevention & control — Autoimmunity/immunology — B-Lymphocytes/immunology — Clonal Anergy/immunology — Female — Lymphocyte Activation/immunology — Lymphocyte Count — Lymphocyte Depletion — Male — Mice — Mice, Inbred C57BL — Mice, Inbred DBA — Mice, Knockout
Identifiers		DOI: 10.4049/jimmunol.1302672 PMID: 24442438
Full text		Article (Published version) (1.8 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine fondamentale / Département de pathologie et immunologie
Research group		Groupe Reith Walter (pathologie et immunologie) (282)
Citation (ISO format)		HARDY, Ian R et al. Anti-CD79 antibody induces B cell anergy that protects against autoimmunity. In: Journal of Immunology, 2014, vol. 192, n° 4, p. 1641-50. doi: 10.4049/jimmunol.1302672 https://archive-ouverte.unige.ch/unige:36446