UNIGE document Scientific Article
previous document  unige:36215  next document
add to browser collection

The molecular scanner: concept and developments

Authors show hidden authors show all authors [1 - 9]
Published in Current opinion in biotechnology. 2004, vol. 15, no. 1, p. 17-23
Abstract Approaches aimed at deciphering the proteome have illustrated the need for relatively complex and highly sensitive methodologies. The major elements of proteome analysis, such as powerful protein separation and enzymatic processing, mass spectrometry and dedicated bioinformatics have been assembled in the development of the molecular scanner. This highly flexible and data-rich approach has combined the power of electrophoretic protein separation, the simultaneous digestion and transfer of proteins through an enzymatic membrane, the immediate use of the MALDI mass spectrometer to scan a collecting membrane, and the development of dedicated bioinformatics tools to perform protein identification and molecular imaging of the proteome. Clinical applications of the molecular scanner have also started to be developed for disease diagnosis in biological material.
Keywords AnimalsBiotechnology/instrumentation/methods/trendsElectrophoresis, Gel, Two-Dimensional/instrumentation/methodsEquipment DesignGene Expression Profiling/instrumentation/methods/trendsHumansProteins/analysis/chemistryProteomics/instrumentation/methods/trendsSequence Analysis, Protein/instrumentation/methods/trendsSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/instrumentation/methods/trendsSystems IntegrationUser-Computer Interface
PMID: 15102461
Full text
Article (Published version) (205 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Research group Groupe de Protéomique biomédicale (635)
(ISO format)
BINZ, Pierre-Alain et al. The molecular scanner: concept and developments. In: Current opinion in biotechnology, 2004, vol. 15, n° 1, p. 17-23. doi: 10.1016/j.copbio.2003.12.003 https://archive-ouverte.unige.ch/unige:36215

494 hits

0 download


Deposited on : 2014-04-30

Export document
Format :
Citation style :