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Title

The molecular scanner: concept and developments

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Published in Current Opinion in Biotechnology. 2004, vol. 15, no. 1, p. 17-23
Abstract Approaches aimed at deciphering the proteome have illustrated the need for relatively complex and highly sensitive methodologies. The major elements of proteome analysis, such as powerful protein separation and enzymatic processing, mass spectrometry and dedicated bioinformatics have been assembled in the development of the molecular scanner. This highly flexible and data-rich approach has combined the power of electrophoretic protein separation, the simultaneous digestion and transfer of proteins through an enzymatic membrane, the immediate use of the MALDI mass spectrometer to scan a collecting membrane, and the development of dedicated bioinformatics tools to perform protein identification and molecular imaging of the proteome. Clinical applications of the molecular scanner have also started to be developed for disease diagnosis in biological material.
Keywords AnimalsBiotechnology/instrumentation/methods/trendsElectrophoresis, Gel, Two-Dimensional/instrumentation/methodsEquipment DesignGene Expression Profiling/instrumentation/methods/trendsHumansProteins/analysis/chemistryProteomics/instrumentation/methods/trendsSequence Analysis, Protein/instrumentation/methods/trendsSpectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/instrumentation/methods/trendsSystems IntegrationUser-Computer Interface
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PMID: 15102461
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Research group Groupe de Protéomique biomédicale (635)
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BINZ, Pierre-Alain et al. The molecular scanner: concept and developments. In: Current Opinion in Biotechnology, 2004, vol. 15, n° 1, p. 17-23. https://archive-ouverte.unige.ch/unige:36215

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Deposited on : 2014-04-30

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