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Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver

Burri, Emanuel
Steuerwald, Michael
Cathomas, Gieri
Meier, Rémy
Published in European Journal of Gastroenterology and Hepatology. 2006, vol. 18, no. 4, p. 437-41
Abstract Liver-cell adenomas are benign lesions of the liver occurring predominantly in young women. Hepatocellular carcinomas in most of the cases arise in a cirrhotic liver during the fifth or sixth decade. We describe the case of a 40-year-old woman in whom work-up for epigastric pain revealed a peptic ulcer and a large hepatic mass. Tests for chronic liver diseases were negative. Imaging findings and biopsy specimens of the tumour were inconclusive. The tumour was surgically removed and a hepatocellular carcinoma arising within a liver-cell adenoma in a non-cirrhotic liver was found. Malignant transformation of liver-cell adenoma has only been reported in a few case reports. Mechanisms of transformation remain unclear. The imaging findings as well as histological features are presented in detail and the literature is discussed.
Keywords Adenoma, Liver Cell/pathologyAdultCarcinoma, Hepatocellular/pathologyFemaleHumansLiver Neoplasms/pathologyNeoplasms, Multiple Primary/pathology
PMID: 16538118
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Research groups Hépatologie chirurgicale (327)
Métastases du foie (657)
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BURRI, Emanuel et al. Hepatocellular carcinoma in a liver-cell adenoma within a non-cirrhotic liver. In: European Journal of Gastroenterology and Hepatology, 2006, vol. 18, n° 4, p. 437-41. https://archive-ouverte.unige.ch/unige:36210

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Deposited on : 2014-04-30

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