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Title

Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells
Authors
Geindre, Sylvie Françoise
Kruithof, Egbert
Published in Cardiovascular Research. 2011, vol. 90, no. 3, p. 457-63
Abstract Tissue-type plasminogen activator (t-PA) is produced by endothelial cells (EC) and is responsible for the removal of intravascular fibrin deposits. We investigated whether expression of t-PA by EC is under epigenetic control.
Keywords Base Sequence — Cells, Cultured — DNA Methylation — DNA Primers/genetics — Endothelial Cells/drug effects/metabolism — Epigenesis, Genetic/drug effects — Hepatocytes/metabolism — Histone Deacetylase Inhibitors/pharmacology — Histone Deacetylases/metabolism — Histones/metabolism — Humans — Promoter Regions, Genetic — RNA, Messenger/genetics/metabolism — Tissue Plasminogen Activator/biosynthesis/genetics
Identifiers
PMID: 21282301
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Article (Published version) (285 Kb) - public document Free access
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group Endothélium vasculaire (11)
Citation
(ISO format) 		GEINDRE, Sylvie Françoise, KRUITHOF, Egbert. Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells. In: Cardiovascular Research, 2011, vol. 90, n° 3, p. 457-63. https://archive-ouverte.unige.ch/unige:36185

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Deposited on : 2014-04-29

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