en
Scientific article
Open access
English

Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells

Published inCardiovascular research, vol. 90, no. 3, p. 457-463
Publication date2011
Abstract

Tissue-type plasminogen activator (t-PA) is produced by endothelial cells (EC) and is responsible for the removal of intravascular fibrin deposits. We investigated whether expression of t-PA by EC is under epigenetic control.

Keywords
  • Base Sequence
  • Cells, Cultured
  • DNA Methylation
  • DNA Primers/genetics
  • Endothelial Cells/drug effects/metabolism
  • Epigenesis, Genetic/drug effects
  • Hepatocytes/metabolism
  • Histone Deacetylase Inhibitors/pharmacology
  • Histone Deacetylases/metabolism
  • Histones/metabolism
  • Humans
  • Promoter Regions, Genetic
  • RNA, Messenger/genetics/metabolism
  • Tissue Plasminogen Activator/biosynthesis/genetics
Citation (ISO format)
GEINDRE, Sylvie Françoise, KRUITHOF, Egbert. Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells. In: Cardiovascular research, 2011, vol. 90, n° 3, p. 457–463. doi: 10.1093/cvr/cvr028
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0008-6363
555views
220downloads

Technical informations

Creation04/11/2014 1:52:00 PM
First validation04/11/2014 1:52:00 PM
Update time03/14/2023 9:10:29 PM
Status update03/14/2023 9:10:29 PM
Last indexation01/16/2024 9:52:01 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack