Scientific article
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Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells

Published inCardiovascular research, vol. 90, no. 3, p. 457-463
Publication date2011
Abstract

Tissue-type plasminogen activator (t-PA) is produced by endothelial cells (EC) and is responsible for the removal of intravascular fibrin deposits. We investigated whether expression of t-PA by EC is under epigenetic control.

Keywords
  • Base Sequence
  • Cells, Cultured
  • DNA Methylation
  • DNA Primers/genetics
  • Endothelial Cells/drug effects/metabolism
  • Epigenesis, Genetic/drug effects
  • Hepatocytes/metabolism
  • Histone Deacetylase Inhibitors/pharmacology
  • Histone Deacetylases/metabolism
  • Histones/metabolism
  • Humans
  • Promoter Regions, Genetic
  • RNA, Messenger/genetics/metabolism
  • Tissue Plasminogen Activator/biosynthesis/genetics
Citation (ISO format)
GEINDRE, Sylvie Françoise, KRUITHOF, Egbert. Epigenetic control of tissue-type plasminogen activator synthesis in human endothelial cells. In: Cardiovascular research, 2011, vol. 90, n° 3, p. 457–463. doi: 10.1093/cvr/cvr028
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0008-6363
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