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How shall we use the proteomics toolbox for biomarker discovery?

Rabilloud, Thierry
Published in Journal of Proteome Research. 2007, vol. 6, no. 9, p. 3371-6
Abstract Biomarker discovery for clinical purposes is one of the major areas in which proteomics is used. However, despite considerable effort, the successes have been relatively scarce. In this perspective paper, we try to highlight and analyze the main causes for this limited success, and to suggest alternate strategies, which will avoid them, without eluding the foreseeable weak points of these strategies. Two major strategies are analyzed, namely, the switch from body fluids to cell and tissues for the initial biomarker discovery step or, if body fluids must be analyzed, the implementation of highly selective protein selection strategies.
Keywords AnimalsBiological Markers/metabolismBlood Proteins/chemistryCerebrospinal Fluid/metabolismComputational BiologyDatabases, ProteinHumansPeptide MappingProteomeProteomics/methods/trendsResearch/trends
PMID: 17655344
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Research group Chimie et protéomique clinique (270)
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LESCUYER, Pierre, HOCHSTRASSER, Denis, RABILLOUD, Thierry. How shall we use the proteomics toolbox for biomarker discovery?. In: Journal of Proteome Research, 2007, vol. 6, n° 9, p. 3371-6. doi: 10.1021/pr0702060 https://archive-ouverte.unige.ch/unige:35970

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Deposited on : 2014-04-23

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