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Title

Heart-fatty acid-binding protein as a marker for early detection of acute myocardial infarction and stroke

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Published in Molecular Diagnosis. 2005, vol. 9, no. 1, p. 1-7
Abstract Heart-fatty acid-binding protein (H-FABP) is a small cytosolic protein involved in intracellular fatty acid transport. This protein, highly concentrated in the heart, is quickly released into plasma after myocardial injury. Results from numerous studies suggest that H-FABP is an excellent marker for the early detection of myocardial damage. H-FABP is also expressed in the brain, although in lower concentrations than in the heart. Recent preliminary studies also investigated the usefulness of H-FABP for the diagnosis of acute and chronic neurological disorders. These potential applications of H-FABP in clinical practice are reviewed in this article, with a strong focus on the early diagnosis of acute myocardial infarction and stroke.
Keywords Acute DiseaseBiological Markers/analysisBrain Injuries/diagnosisCarrier Proteins/analysisEarly DiagnosisFatty Acid-Binding ProteinsHumansMyocardial Infarction/diagnosisNeurodegenerative Diseases/diagnosisStroke/diagnosis
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PMID: 16035729
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Research group Chimie et protéomique clinique (270)
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LESCUYER, Pierre et al. Heart-fatty acid-binding protein as a marker for early detection of acute myocardial infarction and stroke. In: Molecular Diagnosis, 2005, vol. 9, n° 1, p. 1-7. https://archive-ouverte.unige.ch/unige:35969

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Deposited on : 2014-04-22

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