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Dual-Task Assessment in Natalizumab-Treated Multiple Sclerosis Patients

Published in European Neurology. 2014, vol. 71, no. 5-6, p. 247-251
Abstract Background: To study the 1-year evolution of quantitative dual-task gait parameters in comparison with single-task gait parameters and detailed neuropsychological assessment in patients with multiple sclerosis (MS) treated with natalizumab. Methods: Walking speed, stride length and stride time during a dual task (walking while forward counting, backward counting, semantic fluency, and phonemic fluency), a single walking task, and a detailed neuropsychological assessment were prospectively measured and assessed twice at the 1-year interval in 9 consecutive patients with MS treated with natalizumab. Results: Dual-task-related gait changes (walking speed, stride length and stride time while performing semantic fluency and walking speed, and stride time while performing phonemic fluency) showed a significant improvement after 1 year of treatment with natalizumab. The single walking task and detailed neuropsychological assessment did not present any modification. Conclusions: Dual-task-related gait changes using a cognitive task with a specific executive demand represent an interesting marker of disease-modifying therapy in patients with MS. © 2014 S. Karger AG, Basel.
PMID: 24503719
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Research groups Laboratoire de cinésiologie (943)
Scléroses en plaques, neuroimmunologie, encéphalite autoimmune expérimentale (843)
Neuropsychologie et neurologie comportementale (951)
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ALLALI, Gilles et al. Dual-Task Assessment in Natalizumab-Treated Multiple Sclerosis Patients. In: European Neurology, 2014, vol. 71, n° 5-6, p. 247-251. doi: 10.1159/000357217 https://archive-ouverte.unige.ch/unige:35887

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Deposited on : 2014-04-22

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