fr
Article scientifique
Anglais

Mid-hindbrain Malformations Due to Drugs Taken During Pregnancy

Publié dansJournal of child neurology, vol. 29, no. 4, p. 538-544
Date de publication2014
Résumé

Although genetic defects are the leading cause of central nervous system malformations including in the posterior fossa, specific malformative patterns should alert the clinician to consider rather a teratogenic etiology. We discuss the imaging features of 2 mid-hindbrain malformations consecutive to the intake of isotretinoin (Roaccuatane®; case 1) and misoprostol (Cytotec®; case 2) during pregnancy and review the pertinent literature. We correlate the morphological appearance of the mid-hindbrain malformation, as seen on high-resolution magnetic resonance imaging to possible drug-induced pathogenetical mechanisms. The recognition of characteristic imaging patterns enables diagnosis of and/or confirmation of suspected drug-induced hindbrain malformations. This has important medicolegal implications and also clinical significance to avoid unsuccessful and misleading genetic testing.

Citation (format ISO)
MERLINI, Laura et al. Mid-hindbrain Malformations Due to Drugs Taken During Pregnancy. In: Journal of child neurology, 2014, vol. 29, n° 4, p. 538–544. doi: 10.1177/0883073812474345
Fichiers principaux (1)
Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal0883-0738
530vues
3téléchargements

Informations techniques

Création14/04/2014 15:44:00
Première validation14/04/2014 15:44:00
Heure de mise à jour14/03/2023 21:08:19
Changement de statut14/03/2023 21:08:19
Dernière indexation16/01/2024 09:44:34
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack