Resistivity measurements were carried out up to 8 GPa on single-crystal and polycrystalline samples of CeCu2Si2 from differing sources in the homogeneity range. The anisotropic response to current direction and small uniaxial stresses was explored, taking advantage of the quasi-hydrostatic environment of the Bridgman anvil cell. It was found that both the superconducting transition temperature Tc and the normal state properties are very sensitive to uniaxial stress, which leads to a shift of the valence instability pressure Pv and a small but significant change in Tc for different orientations with respect to the tetragonal c-axis. The coexistence of superconductivity and residual resistivity close to the Ioffe–Regel limit around 5 GPa provides a compelling argument for the existence of a valence fluctuation mediated pairing interaction at high pressure in CeCu2Si2.