en
Scientific article
English

Effect of positive end-expiratory pressure on regional ventilation distribution during mechanical ventilation after surfactant depletion

Published inAnesthesiology, vol. 119, no. 1, p. 89-100
Publication date2013
Abstract

Ventilator-induced lung injury occurs due to exaggerated local stresses, repeated collapse, and opening of terminal air spaces in poorly aerated dependent lung, and increased stretch in nondependent lung. The aim of this study was to quantify the functional behavior of peripheral lung units in whole-lung lavage-induced surfactant depletion, and to assess the effect of positive end-expiratory pressure.

Keywords
  • Animals
  • Bronchoalveolar Lavage
  • Carbon Dioxide/blood
  • Image Processing, Computer-Assisted
  • Lung/radiography
  • Lung Volume Measurements
  • Male
  • Oxygen/blood
  • Positive-Pressure Respiration
  • Pulmonary Atelectasis/physiopathology
  • Pulmonary Surfactants/metabolism
  • Rabbits
  • Respiration, Artificial
  • Respiratory Function Tests
  • Respiratory Mechanics
  • Synchrotrons
  • Tomography, X-Ray Computed
Citation (ISO format)
BAYAT, Sam et al. Effect of positive end-expiratory pressure on regional ventilation distribution during mechanical ventilation after surfactant depletion. In: Anesthesiology, 2013, vol. 119, n° 1, p. 89–100. doi: 10.1097/ALN.0b013e318291c165
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Article (Published version)
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Identifiers
ISSN of the journal0003-3022
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