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Title

Effect of positive end-expiratory pressure on regional ventilation distribution during mechanical ventilation after surfactant depletion

Authors
Porra, Liisa
Suhonen, Heikki
Strengell, Satu
Suortti, Pekka
Sovijärvi, Anssi
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Published in Anesthesiology. 2013, vol. 119, no. 1, p. 89-100
Abstract Ventilator-induced lung injury occurs due to exaggerated local stresses, repeated collapse, and opening of terminal air spaces in poorly aerated dependent lung, and increased stretch in nondependent lung. The aim of this study was to quantify the functional behavior of peripheral lung units in whole-lung lavage-induced surfactant depletion, and to assess the effect of positive end-expiratory pressure.
Keywords AnimalsBronchoalveolar LavageCarbon Dioxide/bloodImage Processing, Computer-AssistedLung/radiographyLung Volume MeasurementsMaleOxygen/bloodPositive-Pressure RespirationPulmonary Atelectasis/physiopathologyPulmonary Surfactants/metabolismRabbitsRespiration, ArtificialRespiratory Function TestsRespiratory MechanicsSynchrotronsTomography, X-Ray Computed
Identifiers
PMID: 23559029
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Structures
Research group Enfants et hyperréactivité bronchique (69)
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(ISO format)
BAYAT, Sam et al. Effect of positive end-expiratory pressure on regional ventilation distribution during mechanical ventilation after surfactant depletion. In: Anesthesiology, 2013, vol. 119, n° 1, p. 89-100. https://archive-ouverte.unige.ch/unige:35598

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Deposited on : 2014-04-09

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