Reduced brain cortical folding in schizophrenia revealed in two independent samples

Nesvåg, Ragnar; Schaer, Marie; Haukvik, Unn K; Westlye, Lars T; Rimol, Lars M; Lange, Elisabeth H; Hartberg, Cecilie B; Ottet, Marie-Christine; Melle, Ingrid; Andreassen, Ole A; Jönsson, Erik G; Agartz, Ingrid; Eliez, Stéphan

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Title		Reduced brain cortical folding in schizophrenia revealed in two independent samples
Authors		Nesvåg, Ragnar Schaer, Marie Haukvik, Unn K Westlye, Lars T Rimol, Lars M Lange, Elisabeth H Hartberg, Cecilie B Ottet, Marie-Christine Melle, Ingrid Andreassen, Ole A Jönsson, Erik G Agartz, Ingrid Eliez, Stéphan show all authors [1 - 13]
Published in		Schizophrenia Research. 2014, vol. 152, no. 2-3, p. 333-8
Abstract		The cerebral cortex is highly convoluted, and principal folding patterns are determined early in life. Degree of cortical folding in adult life may index aberrations in brain development. Results from previous studies of cortical folding in schizophrenia are inconsistent. Here we investigated cortical folding patterns in the hitherto largest sample of patients with schizophrenia drawn from two independent cohorts. Magnetic resonance imaging scans were acquired from 207 patients and 206 healthy subjects recruited to two separate research projects in Sweden and Norway. Local gyrification index (lGI) was estimated continuously across the cortex using automated methods. Group differences in lGI were analyzed using general linear models. Patients had lower lGI in three large clusters of the cortex with peak differences found in the left precentral gyrus, right middle temporal gyrus, and right precuneus. Similar, although not completely overlapping results were found when the two cohorts were analyzed separately. There were no significant interaction effects between age and diagnosis and gender and diagnosis. The finding of reduced degree of folding in large regions of the cerebral cortex across two independent samples indicates that reduced gyrification is an inherent feature of the brain pathology in schizophrenia.
Identifiers		DOI: 10.1016/j.schres.2013.11.032 PMID: 24365403
Full text		Article (Published version) (441 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research group		Laboratoire d'imagerie et de psychopathologie développementale (693)
Citation (ISO format)		NESVÅG, Ragnar et al. Reduced brain cortical folding in schizophrenia revealed in two independent samples. In: Schizophrenia Research, 2014, vol. 152, n° 2-3, p. 333-8. https://archive-ouverte.unige.ch/unige:35459