Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps

Wettstein, Reto; Mörsdorf, Philipp; Bächle, Annick; Amon, Michaela; Pittet Cuenod, Brigitte Maud; Menger, Michael D; Harder, Yves

doi:10.1007/s00423-007-0163-8

Scientific article

English

Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps

ContributorsWettstein, Reto; Mörsdorf, Philipp; Bächle, Annick; Amon, Michaela; Pittet Cuenod, Brigitte Maud; Menger, Michael D; Harder, Yves

Published inLangenbeck's archives of surgery, vol. 392, no. 3, p. 331-338

Collection

Open Access - Licence nationale Springer

Publication date2007

Abstract

Insufficient perfusion of distal flap areas, which may lead to partial necrosis, still represents a challenge in reconstructive surgery. In the process of microvascular and endothelial dysfunction, endothelins (ETs) and their receptors may play an important role. Therefore, the aim of the study was to investigate in a chronic in vivo model the effect of various ET-receptor antagonists in critically perfused flap tissue.

Keywords

Animals
Arterioles/pathology/physiopathology
Graft Survival
Ischemia/physiopathology
Mice
Mice, Inbred C57BL
Microcirculation
Microscopy, Fluorescence
Models, Animal
Necrosis
Oligopeptides/pharmacology
Peptides, Cyclic/pharmacology
Piperidines/pharmacology
Receptor, Endothelin A/antagonists & inhibitors
Receptor, Endothelin B/antagonists & inhibitors
Regional Blood Flow
Surgical Flaps/blood supply/pathology
Time Factors
Venules/pathology/physiopathology

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de chirurgie

Research groups

Groupe Pittet Cuenod Brigitte (chirurgie plastique et reconstructive) (96)

Citation (ISO format)

WETTSTEIN, Reto et al. Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps. In: Langenbeck’s archives of surgery, 2007, vol. 392, n° 3, p. 331–338. doi: 10.1007/s00423-007-0163-8

Article (Published version)

Identifiers

PID : unige:35290
DOI : 10.1007/s00423-007-0163-8
PMID : 17380348

Journal ISSN1435-2443

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364downloads

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Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps

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