Scientific article
OA Policy
English

Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps

Published in

Langenbeck's archives of surgery, vol. 392, no. 3, p. 331-338

Collection

  • Open Access - Licence nationale Springer

Publication date

2007

Abstract

Insufficient perfusion of distal flap areas, which may lead to partial necrosis, still represents a challenge in reconstructive surgery. In the process of microvascular and endothelial dysfunction, endothelins (ETs) and their receptors may play an important role. Therefore, the aim of the study was to investigate in a chronic in vivo model the effect of various ET-receptor antagonists in critically perfused flap tissue.

Keywords

  • Animals
  • Arterioles/pathology/physiopathology
  • Graft Survival
  • Ischemia/physiopathology
  • Mice
  • Mice, Inbred C57BL
  • Microcirculation
  • Microscopy, Fluorescence
  • Models, Animal
  • Necrosis
  • Oligopeptides/pharmacology
  • Peptides, Cyclic/pharmacology
  • Piperidines/pharmacology
  • Receptor, Endothelin A/antagonists & inhibitors
  • Receptor, Endothelin B/antagonists & inhibitors
  • Regional Blood Flow
  • Surgical Flaps/blood supply/pathology
  • Time Factors
  • Venules/pathology/physiopathology

Citation (ISO format)

WETTSTEIN, Reto et al. Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps. In: Langenbeck’s archives of surgery, 2007, vol. 392, n° 3, p. 331–338. doi: 10.1007/s00423-007-0163-8

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1435-2443
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490downloads

Technical informations

Creation

01/04/2014 15:42:00

First validation

01/04/2014 15:42:00

Update

14/03/2023 21:05:06

Status update

14/03/2023 21:05:06

Last indexation

30/10/2024 16:42:10
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