en
Scientific article
Open access
English

Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps

Published inLangenbeck's archives of surgery, vol. 392, no. 3, p. 331-338
Collection
  • Open Access - Licence nationale Springer
Publication date2007
Abstract

Insufficient perfusion of distal flap areas, which may lead to partial necrosis, still represents a challenge in reconstructive surgery. In the process of microvascular and endothelial dysfunction, endothelins (ETs) and their receptors may play an important role. Therefore, the aim of the study was to investigate in a chronic in vivo model the effect of various ET-receptor antagonists in critically perfused flap tissue.

Keywords
  • Animals
  • Arterioles/pathology/physiopathology
  • Graft Survival
  • Ischemia/physiopathology
  • Mice
  • Mice, Inbred C57BL
  • Microcirculation
  • Microscopy, Fluorescence
  • Models, Animal
  • Necrosis
  • Oligopeptides/pharmacology
  • Peptides, Cyclic/pharmacology
  • Piperidines/pharmacology
  • Receptor, Endothelin A/antagonists & inhibitors
  • Receptor, Endothelin B/antagonists & inhibitors
  • Regional Blood Flow
  • Surgical Flaps/blood supply/pathology
  • Time Factors
  • Venules/pathology/physiopathology
Citation (ISO format)
WETTSTEIN, Reto et al. Selective blockade of endothelin-B receptor improves survival of critically perfused musculocutaneous flaps. In: Langenbeck’s archives of surgery, 2007, vol. 392, n° 3, p. 331–338. doi: 10.1007/s00423-007-0163-8
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal1435-2443
446views
312downloads

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