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La procalcitonine: un marqueur utile pour l'enfant présentant une infection urinaire

Published in Archives de pédiatrie. 2013, vol. 20, no. 1, p. 54-62
Abstract Urinary tract infections (UTIs) are one of the most common sources of bacterial infections among young febrile children. Accurate diagnosis of acute pyelonephritis (APN) and vesico-ureteral reflux (VUR) are important because of their association with renal scarring, sometimes leading to long-term complications. However, the gold standard examinations are either a DMSA scan for APN and scarring, or cystography for VUR, but both present limitations (feasibility, pain, cost, etc.). Procalcitonin, a reliable marker of bacterial infections, was demonstrated to be a good predictor of renal parenchymal involvement in the acute phase and in late renal scars, as well as of high-grade VUR. These findings need further broad validations and impact studies before being implemented into daily practice. However, procalcitonin may play a role in the complex and still debated picture of which examination should be performed after UTI in children.
Keywords AdolescentBacterial Infections/blood/complications/diagnosisBiological Markers/bloodCalcitonin/bloodChildEvidence-Based MedicineHumansPredictive Value of TestsProtein Precursors/bloodPyelonephritis/blood/diagnosis/microbiologySensitivity and SpecificitySeverity of Illness IndexUrinary Tract Infections/blood/diagnosis/microbiologyVesico-Ureteral Reflux/blood/diagnosis/microbiology
PMID: 23199564
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Research group Etiologie des pneumonies et marqueurs inflammatoires chez l'enfant fébrile (183)
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LEROY, Sandrine, GERVAIX, Alain. La procalcitonine: un marqueur utile pour l'enfant présentant une infection urinaire. In: Archives de pédiatrie, 2013, vol. 20, n° 1, p. 54-62. doi: 10.1016/j.arcped.2012.10.025 https://archive-ouverte.unige.ch/unige:35256

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Deposited on : 2014-04-02

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