en
Scientific article
French

La procalcitonine: un marqueur utile pour l'enfant présentant une infection urinaire

Published inArchives de pédiatrie, vol. 20, no. 1, p. 54-62
Publication date2013
Abstract

Urinary tract infections (UTIs) are one of the most common sources of bacterial infections among young febrile children. Accurate diagnosis of acute pyelonephritis (APN) and vesico-ureteral reflux (VUR) are important because of their association with renal scarring, sometimes leading to long-term complications. However, the gold standard examinations are either a DMSA scan for APN and scarring, or cystography for VUR, but both present limitations (feasibility, pain, cost, etc.). Procalcitonin, a reliable marker of bacterial infections, was demonstrated to be a good predictor of renal parenchymal involvement in the acute phase and in late renal scars, as well as of high-grade VUR. These findings need further broad validations and impact studies before being implemented into daily practice. However, procalcitonin may play a role in the complex and still debated picture of which examination should be performed after UTI in children.

Keywords
  • Adolescent
  • Bacterial Infections/blood/complications/diagnosis
  • Biological Markers/blood
  • Calcitonin/blood
  • Child
  • Evidence-Based Medicine
  • Humans
  • Predictive Value of Tests
  • Protein Precursors/blood
  • Pyelonephritis/blood/diagnosis/microbiology
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Urinary Tract Infections/blood/diagnosis/microbiology
  • Vesico-Ureteral Reflux/blood/diagnosis/microbiology
Citation (ISO format)
LEROY, Sandrine, GERVAIX, Alain. La procalcitonine: un marqueur utile pour l’enfant présentant une infection urinaire. In: Archives de pédiatrie, 2013, vol. 20, n° 1, p. 54–62. doi: 10.1016/j.arcped.2012.10.025
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Article (Published version)
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ISSN of the journal0929-693X
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