Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery

Rubbia-Brandt, Laura; Giostra, Emiliano; Brezault, C; Roth, Arnaud; Andres, Axel; Audard, V; Sartoretti, Pascal Daniel; Dousset, B; Majno, Pietro; Soubrane, O; Chaussade, S; Mentha, Gilles; Terris, B

doi:10.1093/annonc/mdl386

Scientific article

English

Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery

ContributorsRubbia-Brandt, Laura; Giostra, Emiliano; Brezault, C; Roth, Arnaud; Andres, Axel; Audard, V; Sartoretti, Pascal Daniel; Dousset, B; Majno, Pietro; Soubrane, O; Chaussade, S; Mentha, Gilles; Terris, B

Published inAnnals of oncology, vol. 18, no. 2, p. 299-304

Publication date2007

Abstract

The purpose of the study was to characterize histological response to chemotherapy of hepatic colorectal metastases (HCRM), evaluate efficacy of different chemotherapies on histological response, and determine whether tumor regression grading (TRG) of HCRM predicts clinical outcome.

Keywords

Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Camptothecin/administration & dosage/analogs & derivatives
Chemotherapy, Adjuvant
Colorectal Neoplasms/drug therapy/pathology/surgery
Combined Modality Therapy
Disease-Free Survival
Female
Fibrosis/etiology
Fluorouracil/administration & dosage
Humans
Liver Neoplasms/drug therapy/secondary/surgery
Male
Middle Aged
Neoadjuvant Therapy
Neoplasm Recurrence, Local/drug therapy
Neoplasm Staging
Organoplatinum Compounds/administration & dosage
Survival Rate
Treatment Outcome

Affiliation entities

Research groups

Citation (ISO format)

RUBBIA-BRANDT, Laura et al. Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery. In: Annals of oncology, 2007, vol. 18, n° 2, p. 299–304. doi: 10.1093/annonc/mdl386

Article (Published version)

Identifiers

PID : unige:35206
DOI : 10.1093/annonc/mdl386
PMID : 17060484

Journal ISSN0923-7534

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Importance of histological tumor response assessment in predicting the outcome in patients with colorectal liver metastases treated with neo-adjuvant chemotherapy followed by liver surgery

The purpose of the study was to characterize histological response to chemotherapy of hepatic colorectal metastases (HCRM), evaluate efficacy of different chemotherapies on histological response, and determine whether tumor regression grading (TRG) of HCRM predicts clinical outcome.

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