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Scientific article
Open access
English

Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial

Published inJournal of bone and joint surgery. British volume, vol. 89, no. 2, p. 155-159
Publication date2007
Abstract

We examined whether a selective cyclooxygenase-2 (COX-2) inhibitor (celecoxib) was as effective as a non-selective inhibitor (ibuprofen) for the prevention of heterotopic ossification following total hip replacement. A total of 250 patients were randomised to receive celecoxib (200 mg b/d) or ibuprofen (400 mg t.d.s) for ten days after surgery. Anteroposterior radiographs of the pelvis were examined for heterotopic ossification three months after surgery. Of the 250 patients, 240 were available for assessment. Heterotopic ossification was more common in the ibuprofen group (none 40.7% (50), Brooker class I 46.3% (57), classes II and III 13.0% (16)) than in the celecoxib group (none 59.0% (69), Brooker class I 35.9% (42), classes II and III 5.1% (6), p=0.002). Celecoxib was more effective than ibuprofen in preventing heterotopic bone formation after total hip replacement.

Keywords
  • Adult
  • Aged
  • Aged, 80 and over
  • Arthroplasty, Replacement, Hip/adverse effects
  • Cyclooxygenase 2 Inhibitors/therapeutic use
  • Cyclooxygenase Inhibitors/therapeutic use
  • Female
  • Humans
  • Ibuprofen/therapeutic use
  • Male
  • Middle Aged
  • Ossification, Heterotopic/etiology/prevention & control
  • Postoperative Care/methods
  • Prospective Studies
  • Pyrazoles/therapeutic use
  • Severity of Illness Index
  • Single-Blind Method
  • Sulfonamides/therapeutic use
Citation (ISO format)
SAUDAN, Marc et al. Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial. In: Journal of bone and joint surgery. British volume, 2007, vol. 89, n° 2, p. 155–159. doi: 10.1302/0301-620X.89B2.17747
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0301-620X
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442downloads

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