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Title

A 3-month course of long-acting repeatable octreotide (sandostatin LAR) improves portal hypertension in patients with cirrhosis: a randomized controlled study
Authors
Spahr, Laurent François Joséph
Giostra, Emiliano
Frossard, Jean-Louis
Morard, Isabelle
Mentha, Gilles
Hadengue, Antoine
Published in American Journal of Gastroenterology. 2007, vol. 102, no. 7, p. 1397-405
Abstract In patients with cirrhosis, acute octreotide administration may transiently decrease the hepatic venous pressure gradient (HVPG). Information on long-term effects of octreotide is limited and controversial. We evaluated portal and systemic hemodynamics following a prolonged administration of long-acting octreotide in patients with cirrhosis.
Keywords Adult — Aged — Biological Markers/blood — Biopsy — Delayed-Action Preparations — Double-Blind Method — Endothelin-1/blood — Female — Follow-Up Studies — Gastrointestinal Agents/administration & dosage/pharmacokinetics — Humans — Hypertension, Portal/drug therapy/etiology/physiopathology — Immunoenzyme Techniques — Injections, Intramuscular — Liver Cirrhosis/blood/complications/pathology — Male — Middle Aged — Octreotide/administration & dosage/pharmacokinetics — Portal Pressure/physiology — Radioimmunoassay — Retrospective Studies — Time Factors — Treatment Outcome — Urotensins/blood — Vascular Endothelial Growth Factor A/blood
Identifiers
PMID: 17488248
Full text
Article (Published version) (150 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de médecine
Faculté de médecine / Section de médecine clinique / Département de chirurgie
Research groups Hépatologie chirurgicale (327)
Physiopathologie de la pancréatite aiguë (601)
Citation
(ISO format) 		SPAHR, Laurent François Joséph et al. A 3-month course of long-acting repeatable octreotide (sandostatin LAR) improves portal hypertension in patients with cirrhosis: a randomized controlled study. In: American Journal of Gastroenterology, 2007, vol. 102, n° 7, p. 1397-405. doi: 10.1111/j.1572-0241.2007.01262.x https://archive-ouverte.unige.ch/unige:35201

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Deposited on : 2014-04-01

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