Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial

Nielsen, Niklas; Winkel, Per; Cronberg, Tobias; Erlinge, David; Friberg, Hans; Gasche, Yvan; Hassager, Christian; Horn, Janneke; Hovdenes, Jan; Kjaergaard, Jesper; Kuiper, Michael; Pellis, Tommaso; Stammet, Pascal; Wanscher, Michael; Wise, Matt P; Åneman, Anders; Wetterslev, Jørn

doi:10.1186/1745-6215-14-300

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Title		Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial
Authors		Nielsen, Niklas Winkel, Per Cronberg, Tobias Erlinge, David Friberg, Hans Gasche, Yvan Hassager, Christian Horn, Janneke Hovdenes, Jan Kjaergaard, Jesper Kuiper, Michael Pellis, Tommaso Stammet, Pascal Wanscher, Michael Wise, Matt P Åneman, Anders Wetterslev, Jørn show all authors [1 - 17]
Published in		Trials. 2013, vol. 14, 300
Abstract		Animal experimental studies and previous randomized trials suggest an improvement in mortality and neurological function with temperature regulation to hypothermia after cardiac arrest. According to a systematic review, previous trials were small, had a risk of bias, evaluated select populations, and did not treat hyperthermia in the control groups. The optimal target temperature management (TTM) strategy is not known. To prevent outcome reporting bias, selective reporting and data-driven results, we present the a priori defined detailed statistical analysis plan as an update to the previously published outline of the design and rationale for the TTM trial.
Identifiers		DOI: 10.1186/1745-6215-14-300 PMID: 24044764
Full text		Article (Published version) (318 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences
Research group		Groupe Gasche Yvan (Soins intensifs) (501)
Citation (ISO format)		NIELSEN, Niklas et al. Detailed statistical analysis plan for the target temperature management after out-of-hospital cardiac arrest trial. In: Trials, 2013, vol. 14, p. 300. doi: 10.1186/1745-6215-14-300 https://archive-ouverte.unige.ch/unige:35175