en
Scientific article
English

Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model

Published inXenotransplantation, vol. 14, no. 3, p. 243-248
Publication date2007
Abstract

We have previously demonstrated that costimulatory blockade with anti-CD40L monoclonal antibody (mAb) prolongs the survival of non-vascularized concordant rat to mouse islet xenografts. Here, we examine whether signaling through the PD-1/PD-1L pathway is required for the anti-CD40L therapy to prolong concordant islet graft survival using a novel anti-murine PD-1 mAb (clone 4F10).

Keywords
  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD274
  • Antigens, CD80/immunology
  • Antigens, Differentiation/immunology
  • CD40 Ligand/antagonists & inhibitors/immunology
  • Cricetinae
  • Cricetulus/immunology
  • Diabetes Mellitus/chemically induced
  • Disease Models, Animal
  • Graft Survival/immunology
  • Islets of Langerhans Transplantation/immunology/methods
  • Membrane Glycoproteins/antagonists & inhibitors/immunology
  • Mice
  • Mice, Inbred C57BL
  • Peptides/antagonists & inhibitors/immunology
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction/drug effects/immunology
  • Transplantation, Heterologous/immunology/methods
Citation (ISO format)
MAI, Gang et al. Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model. In: Xenotransplantation, 2007, vol. 14, n° 3, p. 243–248. doi: 10.1111/j.1399-3089.2007.00402.x
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0908-665X
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