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Title

Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model

Authors
del Rio, Maria-Luisa
Tian, Jiong
Ramirez, Pablo
Rodriguez-Barbosa, Jose-Ignacio
Published in Xenotransplantation. 2007, vol. 14, no. 3, p. 243-8
Abstract We have previously demonstrated that costimulatory blockade with anti-CD40L monoclonal antibody (mAb) prolongs the survival of non-vascularized concordant rat to mouse islet xenografts. Here, we examine whether signaling through the PD-1/PD-1L pathway is required for the anti-CD40L therapy to prolong concordant islet graft survival using a novel anti-murine PD-1 mAb (clone 4F10).
Keywords AnimalsAntibodies, MonoclonalAntigens, CD274Antigens, CD80/immunologyAntigens, Differentiation/immunologyCD40 Ligand/antagonists & inhibitors/immunologyCricetinaeCricetulus/immunologyDiabetes Mellitus/chemically inducedDisease Models, AnimalGraft Survival/immunologyIslets of Langerhans Transplantation/immunology/methodsMembrane Glycoproteins/antagonists & inhibitors/immunologyMiceMice, Inbred C57BLPeptides/antagonists & inhibitors/immunologyRatsRats, Sprague-DawleySignal Transduction/drug effects/immunologyTransplantation, Heterologous/immunology/methods
Identifiers
PMID: 17489865
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Research group Cultures cellulaires et transplantations (519)
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(ISO format)
MAI, Gang et al. Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model. In: Xenotransplantation, 2007, vol. 14, n° 3, p. 243-8. https://archive-ouverte.unige.ch/unige:35014

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Deposited on : 2014-03-26

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