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Scientific article
English

Defective implant osseointegration under protein undernutrition: prevention by PTH or pamidronate

Published inJournal of bone and mineral research, vol. 22, no. 10, p. 1526-1533
Publication date2007
Abstract

Protein deficiency is associated with impaired titanium osseointegration. We studied whether systemic treatment with PTH or pamidronate could influence the resistance to pull-out of titanium rods implanted into rats proximal tibia under normal and isocaloric low protein intake. PTH or pamidronate prevented the deleterious effects of protein undernutrition on bone microarchitecture close to the implant and on mechanical fixation. PTH even significantly improved implant osseointegration.

Keywords
  • Animal Feed
  • Animals
  • Body Weight/drug effects
  • Diphosphonates/pharmacology
  • Female
  • Implants, Experimental
  • Osseointegration/drug effects/physiology
  • Parathyroid Hormone/pharmacology
  • Proteins/pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Tensile Strength
  • Tomography Scanners, X-Ray Computed
Citation (ISO format)
DAYER, Romain Olivier Pierre et al. Defective implant osseointegration under protein undernutrition: prevention by PTH or pamidronate. In: Journal of bone and mineral research, 2007, vol. 22, n° 10, p. 1526–1533. doi: 10.1359/jbmr.070610
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0884-0431
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