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Title

Defective implant osseointegration under protein undernutrition: prevention by PTH or pamidronate

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Published in Journal of Bone and Mineral Research. 2007, vol. 22, no. 10, p. 1526-33
Abstract Protein deficiency is associated with impaired titanium osseointegration. We studied whether systemic treatment with PTH or pamidronate could influence the resistance to pull-out of titanium rods implanted into rats proximal tibia under normal and isocaloric low protein intake. PTH or pamidronate prevented the deleterious effects of protein undernutrition on bone microarchitecture close to the implant and on mechanical fixation. PTH even significantly improved implant osseointegration.
Keywords Animal FeedAnimalsBody Weight/drug effectsDiphosphonates/pharmacologyFemaleImplants, ExperimentalOsseointegration/drug effects/physiologyParathyroid Hormone/pharmacologyProteins/pharmacologyRatsRats, Sprague-DawleyTensile StrengthTomography Scanners, X-Ray Computed
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PMID: 17563238
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Article (Published version) (2.2 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Nutrition et os (66)
Chirurgie orthopédique et traumatologique (98)
Etudes précliniques de l'ostéoporose (606)
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DAYER, Romain Olivier Pierre et al. Defective implant osseointegration under protein undernutrition: prevention by PTH or pamidronate. In: Journal of Bone and Mineral Research, 2007, vol. 22, n° 10, p. 1526-33. https://archive-ouverte.unige.ch/unige:34864

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Deposited on : 2014-03-20

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