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An unusual case of hypercortisolism with multiple weight-bearing bone fractures

Papadakis, Georgios
Goumaz, Michel
Published in Clinical Cases in Mineral and Bone Metabolism. 2013, vol. 10, no. 3, p. 213-7
Abstract Glucocorticoid excess, either from exogenous exposure or through endogenous overproduction, is a common cause of secondary osteoporosis. We report a 52-year-old woman presenting with multiple stress fractures of the lower extremities, despite various osteoporosis therapeutic regimens. Investigations led to the diagnosis of hypercortisolism of pituitary origin. Pituitary surgery was unsuccessful, justifying a treatment of ketoconazole. In the absence of densitometric osteoporosis, assessment of bone microstructure using high resolution peripheral quantitative computed tomography revealed alterations of both the cortical and trabecular compartments. This case illustrates that hypercortisolism may cause bone fragility in the absence of marked changes in areal bone mineral density.
PMID: 24554936
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Research group Nutrition et os (66)
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PAPADAKIS, Georgios et al. An unusual case of hypercortisolism with multiple weight-bearing bone fractures. In: Clinical Cases in Mineral and Bone Metabolism, 2013, vol. 10, n° 3, p. 213-7. https://archive-ouverte.unige.ch/unige:34826

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Deposited on : 2014-03-18

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