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Scientific article
English

An unusual case of hypercortisolism with multiple weight-bearing bone fractures

Contributors

Papadakis, Georgios; Uebelhart, Brigitte Florence; Goumaz, Michel; Zawadynski, Sophie; Rizzoli, René

Published in

Clinical cases in mineral and bone metabolism, vol. 10, no. 3, p. 213-217

Publication date

2013

Abstract

Glucocorticoid excess, either from exogenous exposure or through endogenous overproduction, is a common cause of secondary osteoporosis. We report a 52-year-old woman presenting with multiple stress fractures of the lower extremities, despite various osteoporosis therapeutic regimens. Investigations led to the diagnosis of hypercortisolism of pituitary origin. Pituitary surgery was unsuccessful, justifying a treatment of ketoconazole. In the absence of densitometric osteoporosis, assessment of bone microstructure using high resolution peripheral quantitative computed tomography revealed alterations of both the cortical and trabecular compartments. This case illustrates that hypercortisolism may cause bone fragility in the absence of marked changes in areal bone mineral density.

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

PAPADAKIS, Georgios et al. An unusual case of hypercortisolism with multiple weight-bearing bone fractures. In: Clinical cases in mineral and bone metabolism, 2013, vol. 10, n° 3, p. 213–217.

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1724-8914
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Technical informations

Creation

13/03/2014 11:54:00

First validation

13/03/2014 11:54:00

Update

14/03/2023 21:01:37

Status update

14/03/2023 21:01:36

Last indexation

30/10/2024 16:31:07
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