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From sequence to functional understanding: the difficult road ahead

Published in Genome Medicine. 2011, vol. 3, no. 4, p. 21
Abstract DNA sequencing has become cheap, rapid and accurate, allowing us to access thousands of genomes and reveal the extensive variation among individuals. The major problem that arises from this is distinguishing between neutral and pathogenic variants. A recent study by Davis et al., in which a functional screen of all the non-synonymous variants of a newly discovered gene was performed, highlights the value and necessity of characterizing the functional consequences of each genomic variant discovered. This is the main challenge for the advancement of genomic medicine in the years to come.
PMID: 21470392
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Research group Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
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MAKRYTHANASIS, Periklis, ANTONARAKIS, Stylianos. From sequence to functional understanding: the difficult road ahead. In: Genome Medicine, 2011, vol. 3, n° 4, p. 21. https://archive-ouverte.unige.ch/unige:34662

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Deposited on : 2014-03-07

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