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Landscape of transcription in human cells

Djebali, Sarah
Davis, Carrie A
CollaborationWith : Falconnet, Emilie / Robyr, Daniel / Reymond, Alexandre / Antonarakis, Stylianos
Published in Nature. 2012, vol. 489, no. 7414, p. 101-8
Abstract Eukaryotic cells make many types of primary and processed RNAs that are found either in specific subcellular compartments or throughout the cells. A complete catalogue of these RNAs is not yet available and their characteristic subcellular localizations are also poorly understood. Because RNA represents the direct output of the genetic information encoded by genomes and a significant proportion of a cell's regulatory capabilities are focused on its synthesis, processing, transport, modification and translation, the generation of such a catalogue is crucial for understanding genome function. Here we report evidence that three-quarters of the human genome is capable of being transcribed, as well as observations about the range and levels of expression, localization, processing fates, regulatory regions and modifications of almost all currently annotated and thousands of previously unannotated RNAs. These observations, taken together, prompt a redefinition of the concept of a gene.
Keywords AllelesCell LineDNA/geneticsDNA, Intergenic/geneticsEncyclopedias as TopicEnhancer Elements, GeneticExons/geneticsGene Expression ProfilingGenes/geneticsGenome, Human/geneticsGenomicsHumansMolecular Sequence AnnotationPolyadenylation/geneticsProtein Isoforms/geneticsRNA/biosynthesis/geneticsRNA Editing/geneticsRNA Splicing/geneticsRegulatory Sequences, Nucleic Acid/geneticsRepetitive Sequences, Nucleic Acid/geneticsSequence Analysis, RNATranscription, Genetic/geneticsTranscriptome/genetics
PMID: 22955620
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Article (Accepted version) (1.2 MB) - public document Free access
Research group Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
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DJEBALI, Sarah, DAVIS, Carrie A. Landscape of transcription in human cells. In: Nature, 2012, vol. 489, n° 7414, p. 101-8. doi: 10.1038/nature11233 https://archive-ouverte.unige.ch/unige:34643

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Deposited on : 2014-03-07

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