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Title

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

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Published in Retrovirology. 2013, vol. 10, p. 20
Abstract Despite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was shown to be required for HIV-1 infectivity. Some investigators have reported that TNPO3 promotes HIV-1 nuclear import, as would be expected for a karyopherin. Yet, an equal number of investigators have failed to obtain evidence that supports this model. Here, a series of experiments were performed to better elucidate the mechanism by which TNPO3 promotes HIV-1 infectivity.
Keywords Capsid Proteins/metabolismCell LineCytoplasm/virologyGene Knockdown TechniquesHIV-1/physiologyHost-Pathogen InteractionsHumansVirus ReplicationBeta Karyopherins/genetics/metabolismMRNA Cleavage and Polyadenylation Factors/antagonists & inhibitors
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PMID: 23414560
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Article (Published version) (2 MB) - public document Free access
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Research group Pathologie Moléculaire de la Trisomie 21 et le Génome Humain (248)
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(ISO format)
DE IACO, Alberto et al. TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm. In: Retrovirology, 2013, vol. 10, p. 20. https://archive-ouverte.unige.ch/unige:34632

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Deposited on : 2014-03-05

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