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Professional article
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English

TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm

Published inRetrovirology, vol. 10, 20
Publication date2013
Abstract

Despite intensive investigation the mechanism by which HIV-1 reaches the host cell nucleus is unknown. TNPO3, a karyopherin mediating nuclear entry of SR-proteins, was shown to be required for HIV-1 infectivity. Some investigators have reported that TNPO3 promotes HIV-1 nuclear import, as would be expected for a karyopherin. Yet, an equal number of investigators have failed to obtain evidence that supports this model. Here, a series of experiments were performed to better elucidate the mechanism by which TNPO3 promotes HIV-1 infectivity.

Keywords
  • Capsid Proteins/metabolism
  • Cell Line
  • Cytoplasm/virology
  • Gene Knockdown Techniques
  • HIV-1/physiology
  • Host-Pathogen Interactions
  • Humans
  • Virus Replication
  • Beta Karyopherins/genetics/metabolism
  • MRNA Cleavage and Polyadenylation Factors/antagonists & inhibitors
Citation (ISO format)
DE IACO, Alberto et al. TNPO3 protects HIV-1 replication from CPSF6-mediated capsid stabilization in the host cell cytoplasm. In: Retrovirology, 2013, vol. 10, p. 20. doi: 10.1186/1742-4690-10-20
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Article (Published version)
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ISSN of the journal1742-4690
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