Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength

Ammann, Patrick; Badoud-Georges, Isabelle; Barraud, Sébastien; Dayer, Romain Olivier Pierre; Rizzoli, René

doi:10.1359/jbmr.070607

Scientific article

English

Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength

ContributorsAmmann, Patrick; Badoud-Georges, Isabelle; Barraud, Sébastien; Dayer, Romain Olivier Pierre; Rizzoli, René

Published inJournal of bone and mineral research, vol. 22, no. 9, p. 1419-1425

Publication date2007

Abstract

Beside its influence on determinants of bone strength (geometry, microarchitecture), which is likely to be related to a cellular effect, strontium ranelate improves bone tissue quality as evaluated by nanoindentation, increasing elastic modulus, hardness, and dissipated energy in vertebrae of rats treated for 104 wk with daily dose from 0 to 900 mg/kg.

Keywords

Animals
Female
Organometallic Compounds/pharmacology
Rats
Rats, Inbred F344
Spine/drug effects/physiology/radiography
Thiophenes/pharmacology
Tomography, X-Ray Computed

Affiliation

Research group

Citation (ISO format)

AMMANN, Patrick et al. Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength. In: Journal of bone and mineral research, 2007, vol. 22, n° 9, p. 1419–1425. doi: 10.1359/jbmr.070607

Article (Published version)

Identifiers

PID : unige:34505
DOI : 10.1359/jbmr.070607
PMID : 17547534

ISSN of the journal0884-0431

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Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength

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