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Title

Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength

Authors
Barraud, Sébastien
Published in Journal of Bone and Mineral Research. 2007, vol. 22, no. 9, p. 1419-25
Abstract Beside its influence on determinants of bone strength (geometry, microarchitecture), which is likely to be related to a cellular effect, strontium ranelate improves bone tissue quality as evaluated by nanoindentation, increasing elastic modulus, hardness, and dissipated energy in vertebrae of rats treated for 104 wk with daily dose from 0 to 900 mg/kg.
Keywords AnimalsFemaleOrganometallic Compounds/pharmacologyRatsRats, Inbred F344Spine/drug effects/physiology/radiographyThiophenes/pharmacologyTomography, X-Ray Computed
Identifiers
PMID: 17547534
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Article (Published version) (1.1 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Nutrition et os (66)
Chirurgie orthopédique et traumatologique (98)
Etudes précliniques de l'ostéoporose (606)
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(ISO format)
AMMANN, Patrick et al. Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength. In: Journal of Bone and Mineral Research, 2007, vol. 22, n° 9, p. 1419-25. https://archive-ouverte.unige.ch/unige:34505

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Deposited on : 2014-02-27

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