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Optimal implantation site for pancreatic islet transplantation

Merani, S
Emamaullee, J
Shapiro, A M J
Published in British Journal of Surgery. 2008, vol. 95, no. 12, p. 1449-61
Abstract Since the first report of successful pancreatic islet transplantation to reverse hyperglycaemia in diabetic rodents, there has been great interest in determining the optimal site for implantation. Although the portal vein remains the most frequently used site clinically, it is not ideal. About half of the islets introduced into the liver die during or shortly after transplantation. Although many patients achieve insulin independence after portal vein infusion of islets, in the long term most resume insulin injections.
Keywords Adipose Tissue/surgeryAnimalsBone and Bones/surgeryBrain/surgeryDisease Models, AnimalGastrointestinal Tract/surgeryHumansIslets of Langerhans Transplantation/methodsKidney/surgeryMaleMuscles/surgeryPancreas/surgeryPortal Vein/surgerySpleen/surgeryTestis/surgeryThymus Gland/surgery
PMID: 18991254
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Research group Transplantation et hépatologie (905)
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MERANI, S et al. Optimal implantation site for pancreatic islet transplantation. In: British Journal of Surgery, 2008, vol. 95, n° 12, p. 1449-61. doi: 10.1002/bjs.6391 https://archive-ouverte.unige.ch/unige:34448

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Deposited on : 2014-02-25

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