en
Scientific article
English

Optimal implantation site for pancreatic islet transplantation

Published inBritish journal of surgery, vol. 95, no. 12, p. 1449-1461
Publication date2008
Abstract

Since the first report of successful pancreatic islet transplantation to reverse hyperglycaemia in diabetic rodents, there has been great interest in determining the optimal site for implantation. Although the portal vein remains the most frequently used site clinically, it is not ideal. About half of the islets introduced into the liver die during or shortly after transplantation. Although many patients achieve insulin independence after portal vein infusion of islets, in the long term most resume insulin injections.

Keywords
  • Adipose Tissue/surgery
  • Animals
  • Bone and Bones/surgery
  • Brain/surgery
  • Disease Models, Animal
  • Gastrointestinal Tract/surgery
  • Humans
  • Islets of Langerhans Transplantation/methods
  • Kidney/surgery
  • Male
  • Muscles/surgery
  • Pancreas/surgery
  • Portal Vein/surgery
  • Spleen/surgery
  • Testis/surgery
  • Thymus Gland/surgery
Citation (ISO format)
MERANI, S et al. Optimal implantation site for pancreatic islet transplantation. In: British journal of surgery, 2008, vol. 95, n° 12, p. 1449–1461. doi: 10.1002/bjs.6391
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0007-1323
445views
0downloads

Technical informations

Creation02/20/2014 1:51:00 PM
First validation02/20/2014 1:51:00 PM
Update time03/14/2023 8:59:18 PM
Status update03/14/2023 8:59:18 PM
Last indexation01/16/2024 9:16:39 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack