Scientific article

Optimal implantation site for pancreatic islet transplantation

Published inBritish journal of surgery, vol. 95, no. 12, p. 1449-1461
Publication date2008

Since the first report of successful pancreatic islet transplantation to reverse hyperglycaemia in diabetic rodents, there has been great interest in determining the optimal site for implantation. Although the portal vein remains the most frequently used site clinically, it is not ideal. About half of the islets introduced into the liver die during or shortly after transplantation. Although many patients achieve insulin independence after portal vein infusion of islets, in the long term most resume insulin injections.

  • Adipose Tissue/surgery
  • Animals
  • Bone and Bones/surgery
  • Brain/surgery
  • Disease Models, Animal
  • Gastrointestinal Tract/surgery
  • Humans
  • Islets of Langerhans Transplantation/methods
  • Kidney/surgery
  • Male
  • Muscles/surgery
  • Pancreas/surgery
  • Portal Vein/surgery
  • Spleen/surgery
  • Testis/surgery
  • Thymus Gland/surgery
Citation (ISO format)
MERANI, S et al. Optimal implantation site for pancreatic islet transplantation. In: British journal of surgery, 2008, vol. 95, n° 12, p. 1449–1461. doi: 10.1002/bjs.6391
Main files (1)
Article (Published version)
ISSN of the journal0007-1323

Technical informations

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