Natural orifice translumenal endoscopic surgery (NOTES) is an exciting concept bringing scarless surgery a reality consisting in body cavity and organs approach through natural orifices (digestive, female genital, urinary tracts). While new instrumentation necessitated by NOTES is still developing, multiple surgical procedures have been performed with success in human. Whenever this approach combining surgical and endoscopic expertise needs technical improvement and clinical validation, it will have a large impact on the future of surgery related to population demand for scarless surgery. The next decade, will show us if surgery will be performed through NOTES or if minimally invasive surgery will be positively influenced by the technical progress of NOTES to be the most minimally traumatic.