en
Scientific article
Open access
English

Single or repeated antimicrobial photodynamic therapy as adjunct to ultrasonic debridement in residual periodontal pockets: clinical, microbiological, and local biological effects

Published inLasers in medical science, vol. 30, no. 1, p. 27-34
Publication date2015
Abstract

Abstract This study aims to assess in residual periodontal pockets the clinical, microbiological, and local biological effects of antimicrobial photodynamic therapy (PDT), de- livered after ultrasonic instrumentation either once or twice in a 1-week interval. A single center, three-arm randomized longitudinal study was carried out for 6 months. Twenty- eight systemically healthy patients on periodontal mainte- nance with residual pockets (pocket depth (PD) ≥5 mm, clinical attachment loss ≥2 mm, and bleeding upon probing (BOP+)) were included. Residual pockets on three teeth, separated from each other by at least two other teeth, served as study sites. After ultrasonic debridement, they were ran- domly assigned to either PDT delivered twice within 1 week (group A), PDT delivered only once (group B), or sham treatment without activating the laser (group C). Methylene blue was applied with a blunt irrigator tip into the pockets. Sites were irradiated with laser light at a wavelength of 670 nm using a light-diffusing tip introduced into the pocket. Initial PD was 5.9±0.9, 6.3±1.3, and 6.3±1.5 mm in groups A, B, and C, respectively, differences being nonsig- nificant. PD was significantly reduced in all groups. At month 3, PD was significantly lower in groups A (2.9± 1.1 mm; p = 0.04) and B (2.8 ± 1.1 mm; p = 0.03) compared to group C (3.5±1.2 mm). At month 6, none of the sites in group A had persisting pockets PD >4 mm and BOP+, whereas two sites in group B and four sites in group C stayed in this category. Detection frequencies of the studied microorganisms at >1,000 and >100.000 cells/ml did not change significantly from baseline to months 3 or 6 in any group. A significant overall decrease was observed from baseline to month 6 for C-reactive protein, serum amyloid A, fibrinogen, procalcitonin, and α-2 macroglobulin. When looking at the groups separately, C-reactive protein was significantly lower only if the laser had been activated twice (p < 0.05). Other differences between groups were not signif- icant. A single or double episodes of PDT had some additional benefit over ultrasonic instrumentation alone.

Keywords
  • Photodynamic
  • Laser
  • Scaling/root planing
  • Nonsurgical/mechanical
  • Therapy/treatment
  • Periodontitis
Citation (ISO format)
MÜLLER CAMPANILE, Véronique S. et al. Single or repeated antimicrobial photodynamic therapy as adjunct to ultrasonic debridement in residual periodontal pockets: clinical, microbiological, and local biological effects. In: Lasers in medical science, 2015, vol. 30, n° 1, p. 27–34. doi: 10.1007/s10103-013-1337-y
Main files (1)
Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0268-8921
644views
445downloads

Technical informations

Creation02/11/2014 4:51:00 PM
First validation02/11/2014 4:51:00 PM
Update time03/14/2023 8:58:30 PM
Status update03/14/2023 8:58:30 PM
Last indexation01/16/2024 9:14:17 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack