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Getting by with a little help from the right CD4+ T cells

Published inOncoimmunology, vol. 2, no. 9, e25772
Publication date2013
Abstract

Tumor infiltration by effector cells is essential for the efficacy of T cell-based immunotherapeutic approaches against brain malignancies. We found that tumor-associated antigen (TAA)-specific CD8+ T cells are optimally recruited to neoplastic lesions when co-administered with TH1 polarized CD4+ T cells that are also TAA-specific. However, in vitro TH1 polarization is not required for the long-term therapeutic efficacy of the combined transfer of CD4+ and CD8+ T cells.

Keywords
  • Adoptive cell transfer, brain tumors, cytotoxic T lymphocytes, immunotherapy, TH1 CD4+ T cells, TH2 CD4+ T cells, T helper epitope, tumor-associated antigens
Citation (ISO format)
HOEPNER, Sabine, WALKER, Paul Richard. Getting by with a little help from the right CD4+ T cells. In: Oncoimmunology, 2013, vol. 2, n° 9, p. e25772. doi: 10.4161/onci.25772
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ISSN of the journal2162-402X
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Creation11/05/2013 11:28:00 AM
First validation11/05/2013 11:28:00 AM
Update time03/14/2023 8:57:21 PM
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