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Getting by with a little help from the right CD4+ T cells

Published in Oncoimmunology. 2013, vol. 2, no. 9, p. e25772
Abstract Tumor infiltration by effector cells is essential for the efficacy of T cell-based immunotherapeutic approaches against brain malignancies. We found that tumor-associated antigen (TAA)-specific CD8+ T cells are optimally recruited to neoplastic lesions when co-administered with TH1 polarized CD4+ T cells that are also TAA-specific. However, in vitro TH1 polarization is not required for the long-term therapeutic efficacy of the combined transfer of CD4+ and CD8+ T cells.
Keywords Adoptive cell transfer, brain tumors, cytotoxic T lymphocytes, immunotherapy, TH1 CD4+ T cells, TH2 CD4+ T cells, T helper epitope, tumor-associated antigens
PMID: 24244904
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Research group Immunobiologie des tumeurs du cerveau (669)
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HOEPNER, Sabine, WALKER, Paul Richard. Getting by with a little help from the right CD4+ T cells. In: Oncoimmunology, 2013, vol. 2, n° 9, p. e25772. https://archive-ouverte.unige.ch/unige:34086

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Deposited on : 2014-02-04

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