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Démences vasculaires et démences mixtes

Duyckaerts, Charles
Hauw, Jean-Jacques
Published in La presse médicale. 2007, vol. 36, no. 10 Pt 2, p. 1469-76
Abstract The concept of vascular dementia has evolved over the past century to include multiple underlying pathophysiological mechanisms. Neuroimaging techniques offer new and better ways to identify the presence of cerebrovascular pathology, although they do not improve our ability to link these changes to the onset of clinical cognitive impairment. Clinical criteria for vascular dementia have also evolved but they remain imperfect. Most epidemiological studies define mixed dementia as the coexistence of Alzheimer's disease and vascular dementia. Clinicopathologic correlations show a clear association between the concomitant presence of vascular and Alzheimer lesions and the severity of cognitive impairment in mixed dementia and provide strong support for the validity of the mixed dementia concept. Mixed dementia is a very frequent disease that remains underdiagnosed, especially in the elderly. The diagnosis of vascular and mixed dementia remains a clinical challenge and cannot be improved without further studies of clinicopathological correlations and functional neuroimaging. Preventive therapeutic interventions include control of vascular risk factors and especially treatment of hypertension.
Keywords AgedAlzheimer Disease/complications/diagnosis/epidemiologyCADASIL/diagnosisCerebral Amyloid Angiopathy/diagnosisCerebral Infarction/complicationsCognition Disorders/complicationsCohort StudiesDementia, Multi-Infarct/diagnosisDementia, Vascular/complications/diagnosis/epidemiology/etiology/prevention & control/radiographyDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersHumansHypertension/complications/therapyMagnetic Resonance ImagingProspective StudiesRisk FactorsTomography, X-Ray Computed
PMID: 17553655
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Research group Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
(ISO format)
ZEKRY BERGER, Dina Selma, DUYCKAERTS, Charles, HAUW, Jean-Jacques. Démences vasculaires et démences mixtes. In: La presse médicale, 2007, vol. 36, n° 10 Pt 2, p. 1469-76. https://archive-ouverte.unige.ch/unige:34018

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Deposited on : 2014-02-03

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