Scientific article

Démences vasculaires et démences mixtes

Published inLa Presse médicale, vol. 36, no. 10 Pt 2, p. 1469-1476
Publication date2007

The concept of vascular dementia has evolved over the past century to include multiple underlying pathophysiological mechanisms. Neuroimaging techniques offer new and better ways to identify the presence of cerebrovascular pathology, although they do not improve our ability to link these changes to the onset of clinical cognitive impairment. Clinical criteria for vascular dementia have also evolved but they remain imperfect. Most epidemiological studies define mixed dementia as the coexistence of Alzheimer's disease and vascular dementia. Clinicopathologic correlations show a clear association between the concomitant presence of vascular and Alzheimer lesions and the severity of cognitive impairment in mixed dementia and provide strong support for the validity of the mixed dementia concept. Mixed dementia is a very frequent disease that remains underdiagnosed, especially in the elderly. The diagnosis of vascular and mixed dementia remains a clinical challenge and cannot be improved without further studies of clinicopathological correlations and functional neuroimaging. Preventive therapeutic interventions include control of vascular risk factors and especially treatment of hypertension.

  • Aged
  • Alzheimer Disease/complications/diagnosis/epidemiology
  • CADASIL/diagnosis
  • Cerebral Amyloid Angiopathy/diagnosis
  • Cerebral Infarction/complications
  • Cognition Disorders/complications
  • Cohort Studies
  • Dementia, Multi-Infarct/diagnosis
  • Dementia, Vascular/complications/diagnosis/epidemiology/etiology/prevention & control/radiography
  • Diagnosis, Differential
  • Diagnostic and Statistical Manual of Mental Disorders
  • Humans
  • Hypertension/complications/therapy
  • Magnetic Resonance Imaging
  • Prospective Studies
  • Risk Factors
  • Tomography, X-Ray Computed
Citation (ISO format)
ZEKRY BERGER, Dina Selma, DUYCKAERTS, Charles, HAUW, Jean-Jacques. Démences vasculaires et démences mixtes. In: La Presse médicale, 2007, vol. 36, n° 10 Pt 2, p. 1469–1476. doi: 10.1016/j.lpm.2007.04.020
Main files (1)
Article (Published version)
ISSN of the journal0755-4982

Technical informations

Creation11/26/2013 10:49:00 PM
First validation11/26/2013 10:49:00 PM
Update time03/14/2023 8:56:50 PM
Status update03/14/2023 8:56:50 PM
Last indexation08/29/2023 10:26:23 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack