UNIGE document Scientific Article - Review
previous document  unige:34018  next document
add to browser collection
Title

Démences vasculaires et démences mixtes

Authors
Duyckaerts, Charles
Hauw, Jean-Jacques
Published in La presse médicale. 2007, vol. 36, no. 10 Pt 2, p. 1469-76
Abstract The concept of vascular dementia has evolved over the past century to include multiple underlying pathophysiological mechanisms. Neuroimaging techniques offer new and better ways to identify the presence of cerebrovascular pathology, although they do not improve our ability to link these changes to the onset of clinical cognitive impairment. Clinical criteria for vascular dementia have also evolved but they remain imperfect. Most epidemiological studies define mixed dementia as the coexistence of Alzheimer's disease and vascular dementia. Clinicopathologic correlations show a clear association between the concomitant presence of vascular and Alzheimer lesions and the severity of cognitive impairment in mixed dementia and provide strong support for the validity of the mixed dementia concept. Mixed dementia is a very frequent disease that remains underdiagnosed, especially in the elderly. The diagnosis of vascular and mixed dementia remains a clinical challenge and cannot be improved without further studies of clinicopathological correlations and functional neuroimaging. Preventive therapeutic interventions include control of vascular risk factors and especially treatment of hypertension.
Keywords AgedAlzheimer Disease/complications/diagnosis/epidemiologyCADASIL/diagnosisCerebral Amyloid Angiopathy/diagnosisCerebral Infarction/complicationsCognition Disorders/complicationsCohort StudiesDementia, Multi-Infarct/diagnosisDementia, Vascular/complications/diagnosis/epidemiology/etiology/prevention & control/radiographyDiagnosis, DifferentialDiagnostic and Statistical Manual of Mental DisordersHumansHypertension/complications/therapyMagnetic Resonance ImagingProspective StudiesRisk FactorsTomography, X-Ray Computed
Identifiers
PMID: 17553655
Full text
Article (Published version) (307 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research group Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
Citation
(ISO format)
ZEKRY BERGER, Dina Selma, DUYCKAERTS, Charles, HAUW, Jean-Jacques. Démences vasculaires et démences mixtes. In: La presse médicale, 2007, vol. 36, n° 10 Pt 2, p. 1469-76. https://archive-ouverte.unige.ch/unige:34018

192 hits

2 downloads

Update

Deposited on : 2014-02-03

Export document
Format :
Citation style :