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Les démences mixtes. Point de vue neuropathologique

Duyckaerts, Charles
Hauw, Jean-Jacques
Published in Psychologie & neuropsychiatrie du vieillissement.[1760-1703 ]. 2005, vol. 3, no. 4, p. 251-9
Abstract Alzheimer's disease (AD) and vascular dementia (VaD) are the most frequent causes of dementia in the elderly. Although AD can be diagnosed with a very high degree of accuracy, the distinction between pure AD, VaD and mixed dementia (MD), where both pathologies co-exist in the same patient, remains a controversial issue and one of the most difficult diagnostic challenges. MD represents a very frequent pathology, especially in the elderly, as underlined by the neuropathological studies. However, the respective importance of degenerative and vascular lesions, their interaction in the genesis of dementia and the mere existence of mixed dementia are still debated. Accurate diagnosis of MD is of crucial significance for epidemiologic purposes and for preventive and therapeutic strategies. Until recently, pharmacological studies have generally focused on pure diseases, either AD or VaD, and have provided little data on the best therapeutic approach to MD. This review will provide an overview of neuropathological aspects of MD in the elderly, which appears to be one of the most common forms of dementia.
Keywords AgedAlzheimer Disease/complications/pathology/psychologyBlood Vessels/pathologyCerebrovascular CirculationDementia/complications/diagnosis/pathology/psychologyDementia, Vascular/complications/pathology/psychologyHumans
PMID: 16316816
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Research group Démence du sujet âgé, troubles cognitifs, la symptomatologie cognitive (577)
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ZEKRY BERGER, Dina Selma, DUYCKAERTS, Charles, HAUW, Jean-Jacques. Les démences mixtes. Point de vue neuropathologique. In: Psychologie & neuropsychiatrie du vieillissement.[1760-1703 ], 2005, vol. 3, n° 4, p. 251-9. https://archive-ouverte.unige.ch/unige:34014

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Deposited on : 2014-02-03

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