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Title

Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study

Authors
Wandeler, Gilles
Cavassini, Matthias
Kovari, Helen
Battegay, Manuel
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Published in Journal of Infectious Diseases. 2013, vol. 208, no. 9, p. 1454-8
Abstract Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.
Identifiers
PMID: 23901088
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Research group VIH/SIDA (930)
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WANDELER, Gilles et al. Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study. In: Journal of Infectious Diseases, 2013, vol. 208, n° 9, p. 1454-8. https://archive-ouverte.unige.ch/unige:33951

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Deposited on : 2014-01-31

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