Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection

Metzner, Karin J; Scherrer, Alexandra U; Preiswerk, Benjamin; Joos, Beda; von Wyl, Viktor; Leemann, Christine; Rieder, Philip; Braun, Dominique; Grube, Christina; Kuster, Herbert; Böni, Jürg; Yerly Ferrillo, Sabine; Klimkait, Thomas; Aubert, Vincent; Furrer, Hansjakob; Battegay, Manuel; Vernazza, Pietro L; Cavassini, Matthias; Calmy, Alexandra; Bernasconi, Enos; Weber, Rainer; Günthard, Huldrych F

doi:10.1093/infdis/jit310

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Title		Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection
Authors		Metzner, Karin J Scherrer, Alexandra U Preiswerk, Benjamin Joos, Beda von Wyl, Viktor Leemann, Christine Rieder, Philip Braun, Dominique Grube, Christina Kuster, Herbert Böni, Jürg Yerly Ferrillo, Sabine Klimkait, Thomas Aubert, Vincent Furrer, Hansjakob Battegay, Manuel Vernazza, Pietro L Cavassini, Matthias Calmy, Alexandra Bernasconi, Enos Weber, Rainer Günthard, Huldrych F show all authors [1 - 22]
Published in		The Journal of Infectious Diseases. 2013, vol. 208, no. 7, p. 1102-12
Abstract		Drug-resistant human immunodeficiency virus type 1 (HIV-1) minority variants (MVs) are present in some antiretroviral therapy (ART)-naive patients. They may result from de novo mutagenesis or transmission. To date, the latter has not been proven.
Keywords		Adolescent — Adult — Aged — Alleles — Cluster Analysis — Cohort Studies — Drug Resistance, Viral — Female — Genetic Variation — HIV Infections/transmission/virology — HIV-1/drug effects/genetics/isolation & purification — Humans — Male — Middle Aged — Phylogeny — Polymerase Chain Reaction — Sequence Analysis, DNA — Switzerland — Young Adult
Identifiers		DOI: 10.1093/infdis/jit310 PMID: 23847055
Full text		Article (Published version) (725 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine
Research group		VIH/SIDA (930)
Citation (ISO format)		METZNER, Karin J et al. Origin of minority drug-resistant HIV-1 variants in primary HIV-1 infection. In: The Journal of Infectious Diseases, 2013, vol. 208, n° 7, p. 1102-12. doi: 10.1093/infdis/jit310 https://archive-ouverte.unige.ch/unige:33946