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Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance

Schechner, Vered
Temkin, Elizabeth
Carmeli, Yehuda
Schwaber, Mitchell J
Published in Clinical microbiology reviews. 2013, vol. 26, no. 2, p. 289-307
Abstract Bacterial resistance to antibiotics is a growing clinical problem and public health threat. Antibiotic use is a known risk factor for the emergence of antibiotic resistance, but demonstrating the causal link between antibiotic use and resistance is challenging. This review describes different study designs for assessing the association between antibiotic use and resistance and discusses strengths and limitations of each. Approaches to measuring antibiotic use and antibiotic resistance are presented. Important methodological issues such as confounding, establishing temporality, and control group selection are examined.
Keywords Anti-Bacterial Agents/therapeutic useBacterial Infections/drug therapy/epidemiology/microbiologyDrug Resistance, BacterialDrug UtilizationEpidemiologic MethodsHumansPrevalence
PMID: 23554418
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Article (Published version) (1.8 MB) - public document Free access
Research group Epidémiologie et contrôle de la résistance aux antibiotiques (866)
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SCHECHNER, Vered et al. Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance. In: Clinical microbiology reviews, 2013, vol. 26, n° 2, p. 289-307. doi: 10.1128/CMR.00001-13 https://archive-ouverte.unige.ch/unige:33923

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Deposited on : 2014-01-31

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