en
Scientific article
Review
Open access
English

Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance

Published inClinical microbiology reviews, vol. 26, no. 2, p. 289-307
Publication date2013
Abstract

Bacterial resistance to antibiotics is a growing clinical problem and public health threat. Antibiotic use is a known risk factor for the emergence of antibiotic resistance, but demonstrating the causal link between antibiotic use and resistance is challenging. This review describes different study designs for assessing the association between antibiotic use and resistance and discusses strengths and limitations of each. Approaches to measuring antibiotic use and antibiotic resistance are presented. Important methodological issues such as confounding, establishing temporality, and control group selection are examined.

Keywords
  • Anti-Bacterial Agents/therapeutic use
  • Bacterial Infections/drug therapy/epidemiology/microbiology
  • Drug Resistance, Bacterial
  • Drug Utilization
  • Epidemiologic Methods
  • Humans
  • Prevalence
Citation (ISO format)
SCHECHNER, Vered et al. Epidemiological interpretation of studies examining the effect of antibiotic usage on resistance. In: Clinical microbiology reviews, 2013, vol. 26, n° 2, p. 289–307. doi: 10.1128/CMR.00001-13
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Article (Published version)
accessLevelPublic
Identifiers
ISSN of the journal0893-8512
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411downloads

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Creation11/18/2013 4:41:00 PM
First validation11/18/2013 4:41:00 PM
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