Scientific article

Non-alcoholic fatty liver disease and insulin resistance: from bench to bedside

Published inDiabetes & metabolism, vol. 39, no. 1, p. 16-26
Publication date2013

Non-alcoholic fatty liver disease (NAFLD) is now the most frequent chronic liver disease in the developed countries. There is also growing evidence from basic and clinical research that NAFLD has a strong relationship to insulin resistance, which is a key factor in the development of type 2 diabetes. The aim of this review is to summarize the recent important findings linking NAFLD and insulin resistance. Lipid accumulation, particularly of diacylglycerol, appears to be of major importance in this process. Mitochondrial dysfunction, through decreased mitochondrial biogenesis, increases oxidative stress, and ageing also plays an important role. Finally, endoplasmic reticulum stress and inflammation also probably contribute to the development of insulin resistance via mechanisms that are still not well understood. Clinical aspects of NAFLD, such as its diagnosis and management, are also investigated in this review.

  • Fatty Liver/blood/immunology/physiopathology
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Inflammation/blood
  • Insulin Resistance/immunology
  • Liver/metabolism
  • Male
  • Obesity/blood/immunology/physiopathology
  • Oxidative Stress
  • Risk Factors
Citation (ISO format)
GARIANI, Karim, PHILIPPE, Jacques, JORNAYVAZ, François. Non-alcoholic fatty liver disease and insulin resistance: from bench to bedside. In: Diabetes & metabolism, 2013, vol. 39, n° 1, p. 16–26. doi: 10.1016/j.diabet.2012.11.002
Main files (1)
Article (Published version)
ISSN of the journal1262-3636

Technical informations

Creation11/18/2013 3:43:00 PM
First validation11/18/2013 3:43:00 PM
Update time03/14/2023 8:56:11 PM
Status update03/14/2023 8:56:10 PM
Last indexation08/29/2023 10:24:35 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack