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Title

Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial

Authors
Bonnet, Maryline
Bhatt, Nilesh
Baudin, Elisabeth
Silva, Carlota
Michon, Christophe
Taburet, Anne-Marie
Sobry, Agnès
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Published in The Lancet Infectious Diseases. 2013, vol. 13, no. 4, p. 303-12
Abstract In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-based antiretroviral therapy (started at full dose) with an efavirenz-based regimen in co-infected patients.
Keywords AIDS-Related Opportunistic Infections/drug therapyAdultAnti-HIV Agents/administration & dosage/adverse effects/therapeutic useAntitubercular Agents/therapeutic useBenzoxazines/administration & dosage/adverse effects/therapeutic useCoinfectionDrug InteractionsDrug Therapy, CombinationFemaleHIV Infections/drug therapyHumansMaleMozambiqueNevirapine/administration & dosage/adverse effects/therapeutic useTreatment OutcomeTuberculosis/complications/drug therapyTuberculosis, Pulmonary/complications/drug therapy
Identifiers
PMID: 23433590
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Research group VIH/SIDA (930)
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BONNET, Maryline et al. Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial. In: The Lancet Infectious Diseases, 2013, vol. 13, n° 4, p. 303-12. https://archive-ouverte.unige.ch/unige:33917

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Deposited on : 2014-01-30

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