Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial

Bonnet, Maryline; Bhatt, Nilesh; Baudin, Elisabeth; Silva, Carlota; Michon, Christophe; Taburet, Anne-Marie; Ciaffi, Laura; Sobry, Agnès; Bastos, Rui; Nunes, Elizabete; Rouzioux, Christine; Jani, Ilesh; Calmy, Alexandra

doi:10.1016/S1473-3099(13)70007-0

Scientific article

English

Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial

ContributorsBonnet, Maryline; Bhatt, Nilesh; Baudin, Elisabeth; Silva, Carlota; Michon, Christophe; Taburet, Anne-Marie; Ciaffi, Laura; Sobry, Agnès; Bastos, Rui; Nunes, Elizabete; Rouzioux, Christine; Jani, Ilesh; Calmy, Alexandra

Published inLancet. Infectious diseases, vol. 13, no. 4, p. 303-312

Publication date2013

Abstract

In countries with a high incidence of HIV and tuberculosis co-infection, nevirapine and efavirenz are widely used as antiretroviral therapy but both interact with antituberculosis drugs. We aimed to compare efficacy and safety of a nevirapine-based antiretroviral therapy (started at full dose) with an efavirenz-based regimen in co-infected patients.

Keywords

AIDS-Related Opportunistic Infections/drug therapy
Adult
Anti-HIV Agents/administration & dosage/adverse effects/therapeutic use
Antitubercular Agents/therapeutic use
Benzoxazines/administration & dosage/adverse effects/therapeutic use
Coinfection
Drug Interactions
Drug Therapy, Combination
Female
HIV Infections/drug therapy
Humans
Male
Mozambique
Nevirapine/administration & dosage/adverse effects/therapeutic use
Treatment Outcome
Tuberculosis/complications/drug therapy
Tuberculosis, Pulmonary/complications/drug therapy

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Research groups

VIH/SIDA (930)

Citation (ISO format)

BONNET, Maryline et al. Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial. In: Lancet. Infectious diseases, 2013, vol. 13, n° 4, p. 303–312. doi: 10.1016/S1473-3099(13)70007-0

Article (Published version)

Identifiers

PID : unige:33917
DOI : 10.1016/S1473-3099(13)70007-0
PMID : 23433590

ISSN of the journal1473-3099

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Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial

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