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Title

Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections

Authors
Dupuy, Anne-Marie
Philippart, François
Péan, Yves
Lasocki, Sigismond
Chalumeau, Martin
Claessens, Yann-Eric
Quenot, Jean-Pierre
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Published in Annals of Intensive Care. 2013, vol. 3, no. 1, p. 22
Abstract In the context of worldwide increasing antimicrobial resistance, good antimicrobial prescribing in more needed than ever; unfortunately, information available to clinicians often are insufficient to rely on. Biomarkers might provide help for decision-making and improve antibiotic management. The purpose of this expert panel review was to examine currently available literature on the potential role of biomarkers to improve antimicrobial prescribing, by answering three questions: 1) Which are the biomarkers available for this purpose?; 2) What is their potential role in the initiation of antibiotic therapy?; and 3) What is their role in the decision to stop antibiotic therapy? To answer these questions, studies reviewed were limited to recent clinical studies (<15 years), involving a substantial number of patients (>50) and restricted to controlled trials and meta-analyses for answering questions 2 and 3. With regard to the first question concerning routinely available biomarkers, which might be useful for antibiotic management of acute infections, these are currently limited to C-reactive protein (CRP) and procalcitonin (PCT). Other promising biomarkers that may prove useful in the near future but need to undergo more extensive clinical testing include sTREM-1, suPAR, ProADM, and Presepsin. New approaches to biomarkers of infections include point-of-care testing and genomics.
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PMID: 23837559
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Article (Published version) (212 Kb) - public document Free access
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Research group Groupe Pugin Jérôme (Soins intensifs) (587)
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DUPUY, Anne-Marie et al. Role of biomarkers in the management of antibiotic therapy: an expert panel review: I - currently available biomarkers for clinical use in acute infections. In: Annals of Intensive Care, 2013, vol. 3, n° 1, p. 22. https://archive-ouverte.unige.ch/unige:33822

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Deposited on : 2014-01-29

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