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Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome

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Published in Critical Care Medicine. 2013, vol. 41, no. 3, p. 820-32
Abstract A hallmark of sepsis and severe systemic inflammatory response syndrome (SIRS) is the massive recruitment of immature neutrophils from the bone marrow into the circulation (left shift, band forms). Their capacity to participate in innate defense against bacteria is ill defined. We aimed at comparing various innate immune functions of mature vs. immature neutrophils circulating during sepsis and SIRS.
Keywords AgedAged, 80 and overBlood Bactericidal ActivityChemotaxis, Leukocyte/immunologyCytokines/bloodFemaleHumansImmunity, InnateIntensive Care UnitsMaleMiddle AgedNeutrophils/cytology/immunologyPhagocytosis/immunologyProspective StudiesReactive Oxygen Species/metabolismSepsis/complications/immunologySystemic Inflammatory Response Syndrome/immunologyToll-Like Receptors/immunologyTumor Necrosis Factor-alpha/metabolism
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PMID: 23348516
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Research group Groupe Pugin Jérôme (Soins intensifs) (587)
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DRIFTE RODUIT, Geneviève Sophie et al. Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome. In: Critical Care Medicine, 2013, vol. 41, n° 3, p. 820-32. https://archive-ouverte.unige.ch/unige:33820

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Deposited on : 2014-01-29

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