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Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome

Publié dansCritical care medicine, vol. 41, no. 3, p. 820-832
Date de publication2013
Résumé

A hallmark of sepsis and severe systemic inflammatory response syndrome (SIRS) is the massive recruitment of immature neutrophils from the bone marrow into the circulation (left shift, band forms). Their capacity to participate in innate defense against bacteria is ill defined. We aimed at comparing various innate immune functions of mature vs. immature neutrophils circulating during sepsis and SIRS.

Mots-clés
  • Aged
  • Aged, 80 and over
  • Blood Bactericidal Activity
  • Chemotaxis, Leukocyte/immunology
  • Cytokines/blood
  • Female
  • Humans
  • Immunity, Innate
  • Intensive Care Units
  • Male
  • Middle Aged
  • Neutrophils/cytology/immunology
  • Phagocytosis/immunology
  • Prospective Studies
  • Reactive Oxygen Species/metabolism
  • Sepsis/complications/immunology
  • Systemic Inflammatory Response Syndrome/immunology
  • Toll-Like Receptors/immunology
  • Tumor Necrosis Factor-alpha/metabolism
Citation (format ISO)
DRIFTE RODUIT, Geneviève Sophie et al. Innate immune functions of immature neutrophils in patients with sepsis and severe systemic inflammatory response syndrome. In: Critical care medicine, 2013, vol. 41, n° 3, p. 820–832. doi: 10.1097/CCM.0b013e318274647d
Fichiers principaux (1)
Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal0090-3493
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Informations techniques

Création11/12/2013 09:21:00
Première validation11/12/2013 09:21:00
Heure de mise à jour14/03/2023 20:55:14
Changement de statut14/03/2023 20:55:13
Dernière indexation16/01/2024 14:04:18
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